SIKs control osteocyte responses to parathyroid hormone
Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling...
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Nature Portfolio
2016
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oai:doaj.org-article:0cde2d55d46f474080f0807c4fb646c22021-12-02T15:34:11ZSIKs control osteocyte responses to parathyroid hormone10.1038/ncomms131762041-1723https://doaj.org/article/0cde2d55d46f474080f0807c4fb646c22016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13176https://doaj.org/toc/2041-1723Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling to suppress sclerostin.Marc N. WeinYanke LiangOlga GoranssonThomas B. SundbergJinhua WangElizabeth A. WilliamsMaureen J. O’MearaNicolas GoveaBelinda BeqoShigeki NishimoriKenichi NaganoDaniel J. BrooksJanaina S. MartinsBraden CorbinAnthony AnselmoRuslan SadreyevJoy Y. WuKei SakamotoMarc ForetzRamnik J. XavierRoland BaronMary L. BouxseinThomas J. GardellaPaola Divieti-PajevicNathanael S. GrayHenry M. KronenbergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg SIKs control osteocyte responses to parathyroid hormone |
| description |
Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling to suppress sclerostin. |
| format |
article |
| author |
Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg |
| author_facet |
Marc N. Wein Yanke Liang Olga Goransson Thomas B. Sundberg Jinhua Wang Elizabeth A. Williams Maureen J. O’Meara Nicolas Govea Belinda Beqo Shigeki Nishimori Kenichi Nagano Daniel J. Brooks Janaina S. Martins Braden Corbin Anthony Anselmo Ruslan Sadreyev Joy Y. Wu Kei Sakamoto Marc Foretz Ramnik J. Xavier Roland Baron Mary L. Bouxsein Thomas J. Gardella Paola Divieti-Pajevic Nathanael S. Gray Henry M. Kronenberg |
| author_sort |
Marc N. Wein |
| title |
SIKs control osteocyte responses to parathyroid hormone |
| title_short |
SIKs control osteocyte responses to parathyroid hormone |
| title_full |
SIKs control osteocyte responses to parathyroid hormone |
| title_fullStr |
SIKs control osteocyte responses to parathyroid hormone |
| title_full_unstemmed |
SIKs control osteocyte responses to parathyroid hormone |
| title_sort |
siks control osteocyte responses to parathyroid hormone |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/0cde2d55d46f474080f0807c4fb646c2 |
| work_keys_str_mv |
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