SIKs control osteocyte responses to parathyroid hormone

QR Code

SIKs control osteocyte responses to parathyroid hormone

Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Marc N. Wein, Yanke Liang, Olga Goransson, Thomas B. Sundberg, Jinhua Wang, Elizabeth A. Williams, Maureen J. O’Meara, Nicolas Govea, Belinda Beqo, Shigeki Nishimori, Kenichi Nagano, Daniel J. Brooks, Janaina S. Martins, Braden Corbin, Anthony Anselmo, Ruslan Sadreyev, Joy Y. Wu, Kei Sakamoto, Marc Foretz, Ramnik J. Xavier, Roland Baron, Mary L. Bouxsein, Thomas J. Gardella, Paola Divieti-Pajevic, Nathanael S. Gray, Henry M. Kronenberg
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/0cde2d55d46f474080f0807c4fb646c2
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Correction: Corrigendum: SIKs control osteocyte responses to parathyroid hormone
par: Marc N. Wein, et autres
Publié: (2017)

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
par: Tadatoshi Sato, et autres
Publié: (2020)

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
par: Jialiang S. Wang, et autres
Publié: (2021)

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
par: Yasuhito Yahara, et autres
Publié: (2016)

Correction: Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
par: Yasuhito Yahara, et autres
Publié: (2016)

mSphere of Influence: Start with an Interesting Biological Phenomenon
par: Teresa O’Meara
Publié: (2019)

Multiomic analysis of stretched osteocytes reveals processes and signalling linked to bone regeneration and cancer
par: Lívia Santos, et autres
Publié: (2021)

The role of osteocytes in targeted bone remodeling: a mathematical model.
par: Jason M Graham, et autres
Publié: (2013)

Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss
par: Jingke Du, et autres
Publié: (2021)

Author Correction: Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes
par: Naruhiko Sawa, et autres
Publié: (2020)

Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
par: Lei Qin, et autres
Publié: (2021)

Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength
par: Alexandra Aguilar-Perez, et autres
Publié: (2019)

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
par: Scott E. Youlten, et autres
Publié: (2021)

Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells.
par: Sarah H McBride, et autres
Publié: (2014)

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
par: Christina Vrahnas, et autres
Publié: (2019)

FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
par: Xiao-Yu Liu, et autres
Publié: (2018)

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
par: Steve Stegen, et autres
Publié: (2018)

Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
par: Ayumi Shoji-Matsunaga, et autres
Publié: (2017)

Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing
par: Tatsuya Shimizu, et autres
Publié: (2021)

Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH.
par: Ye Yuan, et autres
Publié: (2021)

Effect of health systems context on infant and child mortality in sub-Saharan Africa from 1995 to 2015, a longitudinal cohort analysis
par: Ryan A. Simmons, et autres
Publié: (2021)

Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
par: Christina Vrahnas, et autres
Publié: (2019)

Generation of two multipotent mesenchymal progenitor cell lines capable of osteogenic, mature osteocyte, adipogenic, and chondrogenic differentiation
par: Matthew Prideaux, et autres
Publié: (2021)

Functional and structural characterization of osteocytic MLO-Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro
par: Fanchi Meng, et autres
Publié: (2018)

Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture
par: Jeonghyun Kim, et autres
Publié: (2021)

Vertebral bone microarchitecture and osteocyte characteristics of three toothed whale species with varying diving behaviour
par: Tim Rolvien, et autres
Publié: (2017)

<named-content content-type="genus-species">Cryptococcus neoformans</named-content> Rim101 Is Associated with Cell Wall Remodeling and Evasion of the Host Immune Responses
par: Teresa R. O'Meara, et autres
Publié: (2013)

Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation.
par: Matthew Prideaux, et autres
Publié: (2012)

Novel Insights into <named-content content-type="genus-species">Staphylococcus aureus</named-content> Deep Bone Infections: the Involvement of Osteocytes
par: Dongqing Yang, et autres
Publié: (2018)

Staurosporine Induces Filamentation in the Human Fungal Pathogen <named-content content-type="genus-species">Candida albicans</named-content> via Signaling through Cyr1 and Protein Kinase A
par: Jinglin L. Xie, et autres
Publié: (2017)

Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes
par: Ivor P. Geoghegan, et autres
Publié: (2021)

Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation.
par: Ronald Y Kwon, et autres
Publié: (2012)

Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels
par: Masanobu Kawai, et autres
Publié: (2020)

Abnormal Bone Tissue Organization and Osteocyte Lacunocanalicular Network in Early‐Onset Osteoporosis Due to SGMS2 Mutations
par: Riikka E. Mäkitie, et autres
Publié: (2021)

MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts
par: Huan-Chang Zeng, et autres
Publié: (2017)

Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study.
par: Bernhard Hesse, et autres
Publié: (2014)

EL PODER CONSTITUYENTE PERMANENTE EN MÉXICO Y EL PROBLEMA DE LOS LÍMITES DE LA REFORMA CONSTITUCIONAL
par: Neria Govea,Miguel de J.
Publié: (2018)

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
par: Thu Huyen Nguyen, et autres
Publié: (2021)

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons
par: Maude Gerbaix, et autres
Publié: (2017)

Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21.
par: Elizabeth A Blaber, et autres
Publié: (2013)