Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.
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Nature Portfolio
2018
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oai:doaj.org-article:0ce3127e01234b83a479b73aff61e66c2021-12-02T13:24:24ZApolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis10.1038/s41467-018-05806-02041-1723https://doaj.org/article/0ce3127e01234b83a479b73aff61e66c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05806-0https://doaj.org/toc/2041-1723Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.Xiaohong Ruby XuYiming WangReheman AdiliLining JuChristopher M. SpringJoseph Wuxun JinHong YangMiguel A. D. NevesPingguo ChenYan YangXi LeiYunfeng ChenReid C. GallantMiao XuHailong ZhangJina SongPeifeng KeDan ZhangNaadiya CarrimSi-Yang YuGuangheng ZhuYi-Min SheTerry CyrWenbin FuGuoqing LiuPhilip W. ConnellyMargaret L. RandKhosrow AdeliJohn FreedmanJeffrey E. LeePatrick TsoPatrizia MarcheseW. Sean DavidsonShaun P. JacksonCheng ZhuZaverio M. RuggeriHeyu NiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiaohong Ruby Xu Yiming Wang Reheman Adili Lining Ju Christopher M. Spring Joseph Wuxun Jin Hong Yang Miguel A. D. Neves Pingguo Chen Yan Yang Xi Lei Yunfeng Chen Reid C. Gallant Miao Xu Hailong Zhang Jina Song Peifeng Ke Dan Zhang Naadiya Carrim Si-Yang Yu Guangheng Zhu Yi-Min She Terry Cyr Wenbin Fu Guoqing Liu Philip W. Connelly Margaret L. Rand Khosrow Adeli John Freedman Jeffrey E. Lee Patrick Tso Patrizia Marchese W. Sean Davidson Shaun P. Jackson Cheng Zhu Zaverio M. Ruggeri Heyu Ni Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| description |
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis. |
| format |
article |
| author |
Xiaohong Ruby Xu Yiming Wang Reheman Adili Lining Ju Christopher M. Spring Joseph Wuxun Jin Hong Yang Miguel A. D. Neves Pingguo Chen Yan Yang Xi Lei Yunfeng Chen Reid C. Gallant Miao Xu Hailong Zhang Jina Song Peifeng Ke Dan Zhang Naadiya Carrim Si-Yang Yu Guangheng Zhu Yi-Min She Terry Cyr Wenbin Fu Guoqing Liu Philip W. Connelly Margaret L. Rand Khosrow Adeli John Freedman Jeffrey E. Lee Patrick Tso Patrizia Marchese W. Sean Davidson Shaun P. Jackson Cheng Zhu Zaverio M. Ruggeri Heyu Ni |
| author_facet |
Xiaohong Ruby Xu Yiming Wang Reheman Adili Lining Ju Christopher M. Spring Joseph Wuxun Jin Hong Yang Miguel A. D. Neves Pingguo Chen Yan Yang Xi Lei Yunfeng Chen Reid C. Gallant Miao Xu Hailong Zhang Jina Song Peifeng Ke Dan Zhang Naadiya Carrim Si-Yang Yu Guangheng Zhu Yi-Min She Terry Cyr Wenbin Fu Guoqing Liu Philip W. Connelly Margaret L. Rand Khosrow Adeli John Freedman Jeffrey E. Lee Patrick Tso Patrizia Marchese W. Sean Davidson Shaun P. Jackson Cheng Zhu Zaverio M. Ruggeri Heyu Ni |
| author_sort |
Xiaohong Ruby Xu |
| title |
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| title_short |
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| title_full |
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| title_fullStr |
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| title_full_unstemmed |
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis |
| title_sort |
apolipoprotein a-iv binds αiibβ3 integrin and inhibits thrombosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0ce3127e01234b83a479b73aff61e66c |
| work_keys_str_mv |
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