Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous...

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Autores principales: Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P. Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0ce62822a53e4bae828250fb78660d57
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spelling oai:doaj.org-article:0ce62822a53e4bae828250fb78660d572021-12-02T15:38:35ZLkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 210.1038/ncomms149222041-1723https://doaj.org/article/0ce62822a53e4bae828250fb78660d572017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14922https://doaj.org/toc/2041-1723The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes.Haikuo ZhangChristine Fillmore BrainsonShohei KoyamaAmanda J. RedigTing ChenShuai LiManav GuptaCarolina Garcia-de-AlbaMargherita PaschiniGrit S. Herter-SprieGang LuXin ZhangBryan P. MarshStephanie J. TuminelloChunxiao XuZhao ChenXiaoen WangEsra A. AkbayMei ZhengSangeetha PalakurthiLynette M. ShollAnil K. RustgiDavid J. KwiatkowskiJ Alan DiehlAdam J. BassNorman E. SharplessGlenn DranoffPeter S. HammermanHongbin JiNabeel BardeesyDieter SaurHideo WatanabeCarla F. KimKwok-Kin WongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haikuo Zhang
Christine Fillmore Brainson
Shohei Koyama
Amanda J. Redig
Ting Chen
Shuai Li
Manav Gupta
Carolina Garcia-de-Alba
Margherita Paschini
Grit S. Herter-Sprie
Gang Lu
Xin Zhang
Bryan P. Marsh
Stephanie J. Tuminello
Chunxiao Xu
Zhao Chen
Xiaoen Wang
Esra A. Akbay
Mei Zheng
Sangeetha Palakurthi
Lynette M. Sholl
Anil K. Rustgi
David J. Kwiatkowski
J Alan Diehl
Adam J. Bass
Norman E. Sharpless
Glenn Dranoff
Peter S. Hammerman
Hongbin Ji
Nabeel Bardeesy
Dieter Saur
Hideo Watanabe
Carla F. Kim
Kwok-Kin Wong
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
description The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes.
format article
author Haikuo Zhang
Christine Fillmore Brainson
Shohei Koyama
Amanda J. Redig
Ting Chen
Shuai Li
Manav Gupta
Carolina Garcia-de-Alba
Margherita Paschini
Grit S. Herter-Sprie
Gang Lu
Xin Zhang
Bryan P. Marsh
Stephanie J. Tuminello
Chunxiao Xu
Zhao Chen
Xiaoen Wang
Esra A. Akbay
Mei Zheng
Sangeetha Palakurthi
Lynette M. Sholl
Anil K. Rustgi
David J. Kwiatkowski
J Alan Diehl
Adam J. Bass
Norman E. Sharpless
Glenn Dranoff
Peter S. Hammerman
Hongbin Ji
Nabeel Bardeesy
Dieter Saur
Hideo Watanabe
Carla F. Kim
Kwok-Kin Wong
author_facet Haikuo Zhang
Christine Fillmore Brainson
Shohei Koyama
Amanda J. Redig
Ting Chen
Shuai Li
Manav Gupta
Carolina Garcia-de-Alba
Margherita Paschini
Grit S. Herter-Sprie
Gang Lu
Xin Zhang
Bryan P. Marsh
Stephanie J. Tuminello
Chunxiao Xu
Zhao Chen
Xiaoen Wang
Esra A. Akbay
Mei Zheng
Sangeetha Palakurthi
Lynette M. Sholl
Anil K. Rustgi
David J. Kwiatkowski
J Alan Diehl
Adam J. Bass
Norman E. Sharpless
Glenn Dranoff
Peter S. Hammerman
Hongbin Ji
Nabeel Bardeesy
Dieter Saur
Hideo Watanabe
Carla F. Kim
Kwok-Kin Wong
author_sort Haikuo Zhang
title Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
title_short Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
title_full Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
title_fullStr Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
title_full_unstemmed Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
title_sort lkb1 inactivation drives lung cancer lineage switching governed by polycomb repressive complex 2
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0ce62822a53e4bae828250fb78660d57
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