Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous...
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oai:doaj.org-article:0ce62822a53e4bae828250fb78660d572021-12-02T15:38:35ZLkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 210.1038/ncomms149222041-1723https://doaj.org/article/0ce62822a53e4bae828250fb78660d572017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14922https://doaj.org/toc/2041-1723The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes.Haikuo ZhangChristine Fillmore BrainsonShohei KoyamaAmanda J. RedigTing ChenShuai LiManav GuptaCarolina Garcia-de-AlbaMargherita PaschiniGrit S. Herter-SprieGang LuXin ZhangBryan P. MarshStephanie J. TuminelloChunxiao XuZhao ChenXiaoen WangEsra A. AkbayMei ZhengSangeetha PalakurthiLynette M. ShollAnil K. RustgiDavid J. KwiatkowskiJ Alan DiehlAdam J. BassNorman E. SharplessGlenn DranoffPeter S. HammermanHongbin JiNabeel BardeesyDieter SaurHideo WatanabeCarla F. KimKwok-Kin WongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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Science Q Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
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The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes. |
format |
article |
author |
Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong |
author_facet |
Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong |
author_sort |
Haikuo Zhang |
title |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
title_short |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
title_full |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
title_fullStr |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
title_full_unstemmed |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
title_sort |
lkb1 inactivation drives lung cancer lineage switching governed by polycomb repressive complex 2 |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/0ce62822a53e4bae828250fb78660d57 |
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