Anticancer Activity of Natural and Synthetic Chalcones

Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance to treatment is theleading cause of the inefficiency of current standard therapies. Targeted therapies are the most effect...

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Autores principales:	Teodora Constantinescu, Claudiu N. Lungu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chalcone azole cancer cell line bioactivity ligand–receptor interaction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0cebb13ec64f4f32861fb7962b61fdca
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spelling	oai:doaj.org-article:0cebb13ec64f4f32861fb7962b61fdca2021-11-11T16:47:59ZAnticancer Activity of Natural and Synthetic Chalcones10.3390/ijms2221113061422-00671661-6596https://doaj.org/article/0cebb13ec64f4f32861fb7962b61fdca2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11306https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance to treatment is theleading cause of the inefficiency of current standard therapies. Targeted therapies are the most effective due to the low number of side effects and low resistance. Among the small molecule natural compounds, flavonoids are of particular interest for theidentification of new anticancer agents. Chalcones are precursors to all flavonoids and have many biological activities. The anticancer activity of chalcones is due to the ability of these compounds to act on many targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), and loncocarpine, have been extensively studied and modulated. Modification of the basic structure of chalcones in order to obtain compounds with superior cytotoxic properties has been performed by modulating the aromatic residues, replacing aromatic residues with heterocycles, and obtaining hybrid molecules. A huge number of chalcone derivatives with residues such as diaryl ether, sulfonamide, and amine have been obtained, their presence being favorable for anticancer activity. Modification of the amino group in the structure of aminochalconesis always favorable for antitumor activity. This is why hybrid molecules of chalcones with different nitrogen hetercycles in the molecule have been obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, and 1,2,4-triazoles) are of particular importance for the identification of new anticancer agents.Teodora ConstantinescuClaudiu N. LunguMDPI AGarticlechalconeazolecancercell linebioactivityligand–receptor interactionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11306, p 11306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chalcone azole cancer cell line bioactivity ligand–receptor interaction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	chalcone azole cancer cell line bioactivity ligand–receptor interaction Biology (General) QH301-705.5 Chemistry QD1-999 Teodora Constantinescu Claudiu N. Lungu Anticancer Activity of Natural and Synthetic Chalcones
description	Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance to treatment is theleading cause of the inefficiency of current standard therapies. Targeted therapies are the most effective due to the low number of side effects and low resistance. Among the small molecule natural compounds, flavonoids are of particular interest for theidentification of new anticancer agents. Chalcones are precursors to all flavonoids and have many biological activities. The anticancer activity of chalcones is due to the ability of these compounds to act on many targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), and loncocarpine, have been extensively studied and modulated. Modification of the basic structure of chalcones in order to obtain compounds with superior cytotoxic properties has been performed by modulating the aromatic residues, replacing aromatic residues with heterocycles, and obtaining hybrid molecules. A huge number of chalcone derivatives with residues such as diaryl ether, sulfonamide, and amine have been obtained, their presence being favorable for anticancer activity. Modification of the amino group in the structure of aminochalconesis always favorable for antitumor activity. This is why hybrid molecules of chalcones with different nitrogen hetercycles in the molecule have been obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, and 1,2,4-triazoles) are of particular importance for the identification of new anticancer agents.
format	article
author	Teodora Constantinescu Claudiu N. Lungu
author_facet	Teodora Constantinescu Claudiu N. Lungu
author_sort	Teodora Constantinescu
title	Anticancer Activity of Natural and Synthetic Chalcones
title_short	Anticancer Activity of Natural and Synthetic Chalcones
title_full	Anticancer Activity of Natural and Synthetic Chalcones
title_fullStr	Anticancer Activity of Natural and Synthetic Chalcones
title_full_unstemmed	Anticancer Activity of Natural and Synthetic Chalcones
title_sort	anticancer activity of natural and synthetic chalcones
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0cebb13ec64f4f32861fb7962b61fdca
work_keys_str_mv	AT teodoraconstantinescu anticanceractivityofnaturalandsyntheticchalcones AT claudiunlungu anticanceractivityofnaturalandsyntheticchalcones
_version_	1718432221763731456

Anticancer Activity of Natural and Synthetic Chalcones

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