Salivary gland NK cells are phenotypically and functionally unique.

Natural killer (NK) cells and CD8(+) T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Here we characterize a distinct...

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Autores principales:	Marlowe S Tessmer, Emma C Reilly, Laurent Brossay
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0ced4f1a07e442a5a2f7d1cc5952d930
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spelling	oai:doaj.org-article:0ced4f1a07e442a5a2f7d1cc5952d9302021-11-18T06:03:40ZSalivary gland NK cells are phenotypically and functionally unique.1553-73661553-737410.1371/journal.ppat.1001254https://doaj.org/article/0ced4f1a07e442a5a2f7d1cc5952d9302011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21249177/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Natural killer (NK) cells and CD8(+) T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Here we characterize a distinct NK cell population that resides in the salivary gland, uncommon to any described to date, expressing both mature and immature NK cell markers. Using RORγt reporter mice and nude mice, we also show that the salivary gland NK cells are not lymphoid tissue inducer NK-like cells and are not thymic derived. During the course of murine cytomegalovirus (MCMV) infection, we found that salivary gland NK cells detect the infection and acquire activation markers, but have limited capacity to produce IFN-γ and degranulate. Salivary gland NK cell effector functions are not regulated by iNKT or T(reg) cells, which are mostly absent in the salivary gland. Additionally, we demonstrate that peripheral NK cells are not recruited to this organ even after the systemic infection has been controlled. Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells.Marlowe S TessmerEmma C ReillyLaurent BrossayPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 1, p e1001254 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Marlowe S Tessmer Emma C Reilly Laurent Brossay Salivary gland NK cells are phenotypically and functionally unique.
description	Natural killer (NK) cells and CD8(+) T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Here we characterize a distinct NK cell population that resides in the salivary gland, uncommon to any described to date, expressing both mature and immature NK cell markers. Using RORγt reporter mice and nude mice, we also show that the salivary gland NK cells are not lymphoid tissue inducer NK-like cells and are not thymic derived. During the course of murine cytomegalovirus (MCMV) infection, we found that salivary gland NK cells detect the infection and acquire activation markers, but have limited capacity to produce IFN-γ and degranulate. Salivary gland NK cell effector functions are not regulated by iNKT or T(reg) cells, which are mostly absent in the salivary gland. Additionally, we demonstrate that peripheral NK cells are not recruited to this organ even after the systemic infection has been controlled. Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells.
format	article
author	Marlowe S Tessmer Emma C Reilly Laurent Brossay
author_facet	Marlowe S Tessmer Emma C Reilly Laurent Brossay
author_sort	Marlowe S Tessmer
title	Salivary gland NK cells are phenotypically and functionally unique.
title_short	Salivary gland NK cells are phenotypically and functionally unique.
title_full	Salivary gland NK cells are phenotypically and functionally unique.
title_fullStr	Salivary gland NK cells are phenotypically and functionally unique.
title_full_unstemmed	Salivary gland NK cells are phenotypically and functionally unique.
title_sort	salivary gland nk cells are phenotypically and functionally unique.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0ced4f1a07e442a5a2f7d1cc5952d930
work_keys_str_mv	AT marlowestessmer salivaryglandnkcellsarephenotypicallyandfunctionallyunique AT emmacreilly salivaryglandnkcellsarephenotypicallyandfunctionallyunique AT laurentbrossay salivaryglandnkcellsarephenotypicallyandfunctionallyunique
_version_	1718424648121581568

Salivary gland NK cells are phenotypically and functionally unique.

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