Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations.

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Autores principales:	Alex Martin-Trujillo, Enrique Vidal, Ana Monteagudo-Sánchez, Marta Sanchez-Delgado, Sebastian Moran, Jose Ramon Hernandez Mora, Holger Heyn, Miriam Guitart, Manel Esteller, David Monk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e
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spelling	oai:doaj.org-article:0ced9395b01e4ea4b12aeea8da2c0e0e2021-12-02T14:40:58ZCopy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors10.1038/s41467-017-00639-92041-1723https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00639-9https://doaj.org/toc/2041-1723Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations.Alex Martin-TrujilloEnrique VidalAna Monteagudo-SánchezMarta Sanchez-DelgadoSebastian MoranJose Ramon Hernandez MoraHolger HeynMiriam GuitartManel EstellerDavid MonkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
description	Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations.
format	article
author	Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk
author_facet	Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk
author_sort	Alex Martin-Trujillo
title	Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
title_short	Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
title_full	Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
title_fullStr	Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
title_full_unstemmed	Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
title_sort	copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ced9395b01e4ea4b12aeea8da2c0e0e
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Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

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