Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.

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Autores principales: Jessica Gräb, Isabelle Suárez, Edeltraud van Gumpel, Sandra Winter, Fynn Schreiber, Anna Esser, Christoph Hölscher, Melanie Fritsch, Marc Herb, Michael Schramm, Laurens Wachsmuth, Christian Pallasch, Manolis Pasparakis, Hamid Kashkar, Jan Rybniker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/0cf1b079bcdc4e2c9b9dc63c3752ff0e
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spelling oai:doaj.org-article:0cf1b079bcdc4e2c9b9dc63c3752ff0e2021-12-02T16:57:11ZCorticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition10.1038/s41467-019-08405-92041-1723https://doaj.org/article/0cf1b079bcdc4e2c9b9dc63c3752ff0e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08405-9https://doaj.org/toc/2041-1723Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.Jessica GräbIsabelle SuárezEdeltraud van GumpelSandra WinterFynn SchreiberAnna EsserChristoph HölscherMelanie FritschMarc HerbMichael SchrammLaurens WachsmuthChristian PallaschManolis PasparakisHamid KashkarJan RybnikerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jessica Gräb
Isabelle Suárez
Edeltraud van Gumpel
Sandra Winter
Fynn Schreiber
Anna Esser
Christoph Hölscher
Melanie Fritsch
Marc Herb
Michael Schramm
Laurens Wachsmuth
Christian Pallasch
Manolis Pasparakis
Hamid Kashkar
Jan Rybniker
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
description Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.
format article
author Jessica Gräb
Isabelle Suárez
Edeltraud van Gumpel
Sandra Winter
Fynn Schreiber
Anna Esser
Christoph Hölscher
Melanie Fritsch
Marc Herb
Michael Schramm
Laurens Wachsmuth
Christian Pallasch
Manolis Pasparakis
Hamid Kashkar
Jan Rybniker
author_facet Jessica Gräb
Isabelle Suárez
Edeltraud van Gumpel
Sandra Winter
Fynn Schreiber
Anna Esser
Christoph Hölscher
Melanie Fritsch
Marc Herb
Michael Schramm
Laurens Wachsmuth
Christian Pallasch
Manolis Pasparakis
Hamid Kashkar
Jan Rybniker
author_sort Jessica Gräb
title Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
title_short Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
title_full Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
title_fullStr Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
title_full_unstemmed Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
title_sort corticosteroids inhibit mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0cf1b079bcdc4e2c9b9dc63c3752ff0e
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