Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion pr...

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Autores principales:	Jennifer E. Beane, Sarah A. Mazzilli, Joshua D. Campbell, Grant Duclos, Kostyantyn Krysan, Christopher Moy, Catalina Perdomo, Michael Schaffer, Gang Liu, Sherry Zhang, Hanqiao Liu, Jessica Vick, Samjot S. Dhillon, Suso J. Platero, Steven M. Dubinett, Christopher Stevenson, Mary E. Reid, Marc E. Lenburg, Avrum E. Spira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cf5153a221648e9910fbb6ff4aaf085
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spelling	oai:doaj.org-article:0cf5153a221648e9910fbb6ff4aaf0852021-12-02T15:35:13ZMolecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions10.1038/s41467-019-09834-22041-1723https://doaj.org/article/0cf5153a221648e9910fbb6ff4aaf0852019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09834-2https://doaj.org/toc/2041-1723Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion progression.Jennifer E. BeaneSarah A. MazzilliJoshua D. CampbellGrant DuclosKostyantyn KrysanChristopher MoyCatalina PerdomoMichael SchafferGang LiuSherry ZhangHanqiao LiuJessica VickSamjot S. DhillonSuso J. PlateroSteven M. DubinettChristopher StevensonMary E. ReidMarc E. LenburgAvrum E. SpiraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Beane Sarah A. Mazzilli Joshua D. Campbell Grant Duclos Kostyantyn Krysan Christopher Moy Catalina Perdomo Michael Schaffer Gang Liu Sherry Zhang Hanqiao Liu Jessica Vick Samjot S. Dhillon Suso J. Platero Steven M. Dubinett Christopher Stevenson Mary E. Reid Marc E. Lenburg Avrum E. Spira Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
description	Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion progression.
format	article
author	Jennifer E. Beane Sarah A. Mazzilli Joshua D. Campbell Grant Duclos Kostyantyn Krysan Christopher Moy Catalina Perdomo Michael Schaffer Gang Liu Sherry Zhang Hanqiao Liu Jessica Vick Samjot S. Dhillon Suso J. Platero Steven M. Dubinett Christopher Stevenson Mary E. Reid Marc E. Lenburg Avrum E. Spira
author_facet	Jennifer E. Beane Sarah A. Mazzilli Joshua D. Campbell Grant Duclos Kostyantyn Krysan Christopher Moy Catalina Perdomo Michael Schaffer Gang Liu Sherry Zhang Hanqiao Liu Jessica Vick Samjot S. Dhillon Suso J. Platero Steven M. Dubinett Christopher Stevenson Mary E. Reid Marc E. Lenburg Avrum E. Spira
author_sort	Jennifer E. Beane
title	Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
title_short	Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
title_full	Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
title_fullStr	Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
title_full_unstemmed	Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
title_sort	molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0cf5153a221648e9910fbb6ff4aaf085
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Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

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