Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India

Abstract Neurocysticercosis is a significant cause of epilepsy in the tropics. The present cross-sectional survey was conducted in the socioeconomically backward tea garden community of Assam to gauge the prevalence of neurocysticercosis in patients with active epilepsy and to determine the associat...

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Autores principales:	K. Rekha Devi, Debasish Borbora, Narayan Upadhyay, Dibyajyoti Goswami, S. K. Rajguru, Kanwar Narain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cf7fc186705417893b39690540def8c
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spelling	oai:doaj.org-article:0cf7fc186705417893b39690540def8c2021-12-02T14:25:22ZNeurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India10.1038/s41598-021-86823-w2045-2322https://doaj.org/article/0cf7fc186705417893b39690540def8c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86823-whttps://doaj.org/toc/2045-2322Abstract Neurocysticercosis is a significant cause of epilepsy in the tropics. The present cross-sectional survey was conducted in the socioeconomically backward tea garden community of Assam to gauge the prevalence of neurocysticercosis in patients with active epilepsy and to determine the associated risk factors. In a door to door survey, a total of 1028 individuals from every fifth household of the study Teagarden were enrolled to identify self-reported seizure cases, followed by a neurological examination to confirm the diagnosis of active epilepsy. Patients with active epilepsy underwent clinical, epidemiological, neuroimaging (contrast-enhanced computerized tomography) and immunological evaluations to establish the diagnosis of neurocysticercosis. Clinically confirmed 53 (5.16%) active epilepsy were identified; 45 agreed to further assessment for neurocysticercosis and 19 (42.2%) cases fulfilled either definitive or probable diagnostic criteria for neurocysticercosis. Patients with epilepsy due to neurocysticercosis were more likely to suffer from taeniasis (20.0% vs 0.0%), rear pigs (57.9% vs 15.4%) or have pigs in their neighbourhood (78.9% vs 53.8%) relative to epileptic patients without neurocysticercosis. Rearing pigs (aOR 14.35, 95% CI: 3.98–51.75) or having pigs in the neighbourhood (aOR 12.34, 95% CI: 2.53–60.31) were independent risk factors of neurocysticercosis. In this community, the prevalence of taeniasis (adult worm infection) was 6.6% based on microscopy. The study reports a high prevalence of active epilepsy in the tea garden community of Assam and neurocysticercosis as its primary cause. The high prevalence of taeniasis is also a significant concern.K. Rekha DeviDebasish BorboraNarayan UpadhyayDibyajyoti GoswamiS. K. RajguruKanwar NarainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. Rekha Devi Debasish Borbora Narayan Upadhyay Dibyajyoti Goswami S. K. Rajguru Kanwar Narain Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
description	Abstract Neurocysticercosis is a significant cause of epilepsy in the tropics. The present cross-sectional survey was conducted in the socioeconomically backward tea garden community of Assam to gauge the prevalence of neurocysticercosis in patients with active epilepsy and to determine the associated risk factors. In a door to door survey, a total of 1028 individuals from every fifth household of the study Teagarden were enrolled to identify self-reported seizure cases, followed by a neurological examination to confirm the diagnosis of active epilepsy. Patients with active epilepsy underwent clinical, epidemiological, neuroimaging (contrast-enhanced computerized tomography) and immunological evaluations to establish the diagnosis of neurocysticercosis. Clinically confirmed 53 (5.16%) active epilepsy were identified; 45 agreed to further assessment for neurocysticercosis and 19 (42.2%) cases fulfilled either definitive or probable diagnostic criteria for neurocysticercosis. Patients with epilepsy due to neurocysticercosis were more likely to suffer from taeniasis (20.0% vs 0.0%), rear pigs (57.9% vs 15.4%) or have pigs in their neighbourhood (78.9% vs 53.8%) relative to epileptic patients without neurocysticercosis. Rearing pigs (aOR 14.35, 95% CI: 3.98–51.75) or having pigs in the neighbourhood (aOR 12.34, 95% CI: 2.53–60.31) were independent risk factors of neurocysticercosis. In this community, the prevalence of taeniasis (adult worm infection) was 6.6% based on microscopy. The study reports a high prevalence of active epilepsy in the tea garden community of Assam and neurocysticercosis as its primary cause. The high prevalence of taeniasis is also a significant concern.
format	article
author	K. Rekha Devi Debasish Borbora Narayan Upadhyay Dibyajyoti Goswami S. K. Rajguru Kanwar Narain
author_facet	K. Rekha Devi Debasish Borbora Narayan Upadhyay Dibyajyoti Goswami S. K. Rajguru Kanwar Narain
author_sort	K. Rekha Devi
title	Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
title_short	Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
title_full	Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
title_fullStr	Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
title_full_unstemmed	Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India
title_sort	neurocysticercosis in patients with active epilepsy in the tea garden community of assam, northeast india
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0cf7fc186705417893b39690540def8c
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Neurocysticercosis in patients with active epilepsy in the tea garden community of Assam, Northeast India

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