The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.

<h4>Background</h4>The relationship between severe anemia, red blood cell transfusion and Neonatal necrotizing enterocolitis (NEC) remains controversial. The purpose of this study was to determine the association of severe anemia and RBC transfusion with NEC in neonates.<h4>Methods...

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Autores principales:	Juan Song, Huimin Dong, Falin Xu, Yong Wang, Wendong Li, Zhenzhen Jue, Lele Wei, Yuyang Yue, Changlian Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0cf9f1aa95714cbb9757da06abf9e61f
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spelling	oai:doaj.org-article:0cf9f1aa95714cbb9757da06abf9e61f2021-12-02T20:06:48ZThe association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.1932-620310.1371/journal.pone.0254810https://doaj.org/article/0cf9f1aa95714cbb9757da06abf9e61f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254810https://doaj.org/toc/1932-6203<h4>Background</h4>The relationship between severe anemia, red blood cell transfusion and Neonatal necrotizing enterocolitis (NEC) remains controversial. The purpose of this study was to determine the association of severe anemia and RBC transfusion with NEC in neonates.<h4>Methods</h4>The clinical characteristics of NEC were observed in 467 infants with different birth weights from January 2012 to July 2020. A 1:1 ratio case-control study was performed in very low birth weight (VLBW) infants. Severe anemia, RBC transfusion, and confounding factors, including maternal and perinatal complications, feeding, and antibiotics administration were collected in both groups. Univariate and multivariate analyses were used to investigate effects on the risk of NEC.<h4>Results</h4>The day of NEC onset and mortality were inversely associated with birth weight. In VLBW infants, adjusting for other factors, severe anemia within 72 h [OR = 2.404, P = 0.016], RBC transfusion within 24 h [OR = 4.905, P = 0.016], within 48 h [OR = 5.587, P = 0.008], and within 72 h [OR = 2.858, P = 0.011] increased the risk of NEC.<h4>Conclusion</h4>Both severe anemia and RBC transfusion appears to increase the risk of NEC in VLBW infants. The early prevention and treatment of anemia, strict evaluation of the indications for transfusion and enhanced monitoring after transfusion is encouraged in the NICU.Juan SongHuimin DongFalin XuYong WangWendong LiZhenzhen JueLele WeiYuyang YueChanglian ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254810 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Song Huimin Dong Falin Xu Yong Wang Wendong Li Zhenzhen Jue Lele Wei Yuyang Yue Changlian Zhu The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
description	<h4>Background</h4>The relationship between severe anemia, red blood cell transfusion and Neonatal necrotizing enterocolitis (NEC) remains controversial. The purpose of this study was to determine the association of severe anemia and RBC transfusion with NEC in neonates.<h4>Methods</h4>The clinical characteristics of NEC were observed in 467 infants with different birth weights from January 2012 to July 2020. A 1:1 ratio case-control study was performed in very low birth weight (VLBW) infants. Severe anemia, RBC transfusion, and confounding factors, including maternal and perinatal complications, feeding, and antibiotics administration were collected in both groups. Univariate and multivariate analyses were used to investigate effects on the risk of NEC.<h4>Results</h4>The day of NEC onset and mortality were inversely associated with birth weight. In VLBW infants, adjusting for other factors, severe anemia within 72 h [OR = 2.404, P = 0.016], RBC transfusion within 24 h [OR = 4.905, P = 0.016], within 48 h [OR = 5.587, P = 0.008], and within 72 h [OR = 2.858, P = 0.011] increased the risk of NEC.<h4>Conclusion</h4>Both severe anemia and RBC transfusion appears to increase the risk of NEC in VLBW infants. The early prevention and treatment of anemia, strict evaluation of the indications for transfusion and enhanced monitoring after transfusion is encouraged in the NICU.
format	article
author	Juan Song Huimin Dong Falin Xu Yong Wang Wendong Li Zhenzhen Jue Lele Wei Yuyang Yue Changlian Zhu
author_facet	Juan Song Huimin Dong Falin Xu Yong Wang Wendong Li Zhenzhen Jue Lele Wei Yuyang Yue Changlian Zhu
author_sort	Juan Song
title	The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
title_short	The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
title_full	The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
title_fullStr	The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
title_full_unstemmed	The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
title_sort	association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0cf9f1aa95714cbb9757da06abf9e61f
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The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.

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