Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical protofibril scaffolds, which potentiates DNA sens...

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Autores principales:	Ernest Y. Lee, Changsheng Zhang, Jeremy Di Domizio, Fan Jin, Will Connell, Mandy Hung, Nicolas Malkoff, Veronica Veksler, Michel Gilliet, Pengyu Ren, Gerard C. L. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cfa78d072484607acce93542e7e8977
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0cfa78d072484607acce93542e7e89772021-12-02T15:36:06ZHelical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR910.1038/s41467-019-08868-w2041-1723https://doaj.org/article/0cfa78d072484607acce93542e7e89772019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08868-whttps://doaj.org/toc/2041-1723Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical protofibril scaffolds, which potentiates DNA sensing by TLR9.Ernest Y. LeeChangsheng ZhangJeremy Di DomizioFan JinWill ConnellMandy HungNicolas MalkoffVeronica VekslerMichel GillietPengyu RenGerard C. L. WongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ernest Y. Lee Changsheng Zhang Jeremy Di Domizio Fan Jin Will Connell Mandy Hung Nicolas Malkoff Veronica Veksler Michel Gilliet Pengyu Ren Gerard C. L. Wong Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
description	Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical protofibril scaffolds, which potentiates DNA sensing by TLR9.
format	article
author	Ernest Y. Lee Changsheng Zhang Jeremy Di Domizio Fan Jin Will Connell Mandy Hung Nicolas Malkoff Veronica Veksler Michel Gilliet Pengyu Ren Gerard C. L. Wong
author_facet	Ernest Y. Lee Changsheng Zhang Jeremy Di Domizio Fan Jin Will Connell Mandy Hung Nicolas Malkoff Veronica Veksler Michel Gilliet Pengyu Ren Gerard C. L. Wong
author_sort	Ernest Y. Lee
title	Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
title_short	Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
title_full	Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
title_fullStr	Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
title_full_unstemmed	Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9
title_sort	helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsdna to tlr9
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0cfa78d072484607acce93542e7e8977
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Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

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