Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines

Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives...

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Autores principales:	Jia-Wang Wang, Yan Li, Wan Nie, Zhe Chang, Zi-An Yu, Yi-Fan Zhao, Xi Lu, Yao Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0cfb72108a7845349924ccda087c2aa8
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spelling	oai:doaj.org-article:0cfb72108a7845349924ccda087c2aa82021-12-02T13:33:04ZCatalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines10.1038/s41467-021-21600-x2041-1723https://doaj.org/article/0cfb72108a7845349924ccda087c2aa82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21600-xhttps://doaj.org/toc/2041-1723Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.Jia-Wang WangYan LiWan NieZhe ChangZi-An YuYi-Fan ZhaoXi LuYao FuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia-Wang Wang Yan Li Wan Nie Zhe Chang Zi-An Yu Yi-Fan Zhao Xi Lu Yao Fu Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
description	Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.
format	article
author	Jia-Wang Wang Yan Li Wan Nie Zhe Chang Zi-An Yu Yi-Fan Zhao Xi Lu Yao Fu
author_facet	Jia-Wang Wang Yan Li Wan Nie Zhe Chang Zi-An Yu Yi-Fan Zhao Xi Lu Yao Fu
author_sort	Jia-Wang Wang
title	Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
title_short	Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
title_full	Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
title_fullStr	Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
title_full_unstemmed	Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
title_sort	catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0cfb72108a7845349924ccda087c2aa8
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Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines

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