Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer

Background: Papillary thyroid carcinoma (PTC) is the most prevalent malignancy of the endocrine system. This study was aimed at evaluating the serum substance P (SP) levels, the tissue distribution of Neurokinin-1 receptors (NK1-R), and their possible diagnostic value in PTC. Method: The present cas...

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Autores principales:	Mahdi Asadi, Seyedeh Motahareh Mirdoosti, Saeed Majidi, Nadia Boroumand, Amir-Hossein Jafarian, Seyed Isaac Hashemy
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	thyroid neoplasms substance p nk1r tachykinin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0d003e49f4d2432a86e0680727e407b8
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spelling	oai:doaj.org-article:0d003e49f4d2432a86e0680727e407b82021-11-29T10:40:47ZEvaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer2008-67092008-668710.30476/mejc.2020.85658.1297https://doaj.org/article/0d003e49f4d2432a86e0680727e407b82021-10-01T00:00:00Zhttps://mejc.sums.ac.ir/article_47049_dc58509df3b4723e5fe94cefdc2f9217.pdfhttps://doaj.org/toc/2008-6709https://doaj.org/toc/2008-6687Background: Papillary thyroid carcinoma (PTC) is the most prevalent malignancy of the endocrine system. This study was aimed at evaluating the serum substance P (SP) levels, the tissue distribution of Neurokinin-1 receptors (NK1-R), and their possible diagnostic value in PTC. Method: The present case-control study included 31 healthy volunteers and 31 cases (age range: 25-64, 40.26 ±12.77), who were primarily diagnosed with PTC and were candidates for total thyroidectomy. Pre-operative serum level of SP was measured using a commercial ELISA kit. The tissue distribution of NK1-R was assessed immunohistochemically. Results: The serum level of SP in the patient group was higher than the healthy volunteers (P = 0.005). Besides, the expression of NK1-R was higher in tumoral tissues compared with their normal surroundings (P = 0.005). However, we observed no significant correlation between either SP level or NK1-R expression and the disease stage or lymph node involvement. Conclusion: SP level and NK1-R expression were upregulated in PTC patients, showing the involvement of SP/NK1R complex in PTC pathophysiology. Nonetheless, proposing SP/NK1R as a diagnostic factor requires further studies because we found no correlation between SP/NK1R and clinical stage or lymph node involvement.Mahdi AsadiSeyedeh Motahareh MirdoostiSaeed MajidiNadia BoroumandAmir-Hossein JafarianSeyed Isaac HashemyShiraz University of Medical Sciencesarticlethyroid neoplasmssubstance pnk1rtachykinincancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMiddle East Journal of Cancer , Vol 12, Iss 4, Pp 491-498 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid neoplasms substance p nk1r tachykinin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thyroid neoplasms substance p nk1r tachykinin cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mahdi Asadi Seyedeh Motahareh Mirdoosti Saeed Majidi Nadia Boroumand Amir-Hossein Jafarian Seyed Isaac Hashemy Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
description	Background: Papillary thyroid carcinoma (PTC) is the most prevalent malignancy of the endocrine system. This study was aimed at evaluating the serum substance P (SP) levels, the tissue distribution of Neurokinin-1 receptors (NK1-R), and their possible diagnostic value in PTC. Method: The present case-control study included 31 healthy volunteers and 31 cases (age range: 25-64, 40.26 ±12.77), who were primarily diagnosed with PTC and were candidates for total thyroidectomy. Pre-operative serum level of SP was measured using a commercial ELISA kit. The tissue distribution of NK1-R was assessed immunohistochemically. Results: The serum level of SP in the patient group was higher than the healthy volunteers (P = 0.005). Besides, the expression of NK1-R was higher in tumoral tissues compared with their normal surroundings (P = 0.005). However, we observed no significant correlation between either SP level or NK1-R expression and the disease stage or lymph node involvement. Conclusion: SP level and NK1-R expression were upregulated in PTC patients, showing the involvement of SP/NK1R complex in PTC pathophysiology. Nonetheless, proposing SP/NK1R as a diagnostic factor requires further studies because we found no correlation between SP/NK1R and clinical stage or lymph node involvement.
format	article
author	Mahdi Asadi Seyedeh Motahareh Mirdoosti Saeed Majidi Nadia Boroumand Amir-Hossein Jafarian Seyed Isaac Hashemy
author_facet	Mahdi Asadi Seyedeh Motahareh Mirdoosti Saeed Majidi Nadia Boroumand Amir-Hossein Jafarian Seyed Isaac Hashemy
author_sort	Mahdi Asadi
title	Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
title_short	Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
title_full	Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
title_fullStr	Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
title_full_unstemmed	Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer
title_sort	evaluation of serum substance p level and tissue distribution of nk-1 receptor in papillary thyroid cancer
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/0d003e49f4d2432a86e0680727e407b8
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Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer

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