The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis

GRIP1 cooperates with the glucocorticoid receptor to repress inflammatory genes. Here the authors show that GRIP1 also controls macrophage polarization, by promoting KLF4-driven activation in response to IL-4, and that mice lacking GRIP1 in macrophages develop severe metabolic dysfunction on a high-...

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Autores principales:	Maddalena Coppo, Yurii Chinenov, Maria A. Sacta, Inez Rogatsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d0322f78ea542849845576d691d6376
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spelling	oai:doaj.org-article:0d0322f78ea542849845576d691d63762021-12-02T16:57:00ZThe transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis10.1038/ncomms122542041-1723https://doaj.org/article/0d0322f78ea542849845576d691d63762016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12254https://doaj.org/toc/2041-1723GRIP1 cooperates with the glucocorticoid receptor to repress inflammatory genes. Here the authors show that GRIP1 also controls macrophage polarization, by promoting KLF4-driven activation in response to IL-4, and that mice lacking GRIP1 in macrophages develop severe metabolic dysfunction on a high-fat diet.Maddalena CoppoYurii ChinenovMaria A. SactaInez RogatskyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maddalena Coppo Yurii Chinenov Maria A. Sacta Inez Rogatsky The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
description	GRIP1 cooperates with the glucocorticoid receptor to repress inflammatory genes. Here the authors show that GRIP1 also controls macrophage polarization, by promoting KLF4-driven activation in response to IL-4, and that mice lacking GRIP1 in macrophages develop severe metabolic dysfunction on a high-fat diet.
format	article
author	Maddalena Coppo Yurii Chinenov Maria A. Sacta Inez Rogatsky
author_facet	Maddalena Coppo Yurii Chinenov Maria A. Sacta Inez Rogatsky
author_sort	Maddalena Coppo
title	The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
title_short	The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
title_full	The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
title_fullStr	The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
title_full_unstemmed	The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
title_sort	transcriptional coregulator grip1 controls macrophage polarization and metabolic homeostasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0d0322f78ea542849845576d691d6376
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The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis

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