Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis...

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Autores principales:	Alexandra Schischko, Nikolaos Kaplaneris, Torben Rogge, Giedre Sirvinskaite, Jongwoo Son, Lutz Ackermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d0672b6c73c4b54bd92fda2d14eeb00
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id	oai:doaj.org-article:0d0672b6c73c4b54bd92fda2d14eeb00
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spelling	oai:doaj.org-article:0d0672b6c73c4b54bd92fda2d14eeb002021-12-02T14:39:18ZLate-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis10.1038/s41467-019-11395-32041-1723https://doaj.org/article/0d0672b6c73c4b54bd92fda2d14eeb002019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11395-3https://doaj.org/toc/2041-1723Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis.Alexandra SchischkoNikolaos KaplanerisTorben RoggeGiedre SirvinskaiteJongwoo SonLutz AckermannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra Schischko Nikolaos Kaplaneris Torben Rogge Giedre Sirvinskaite Jongwoo Son Lutz Ackermann Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
description	Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis.
format	article
author	Alexandra Schischko Nikolaos Kaplaneris Torben Rogge Giedre Sirvinskaite Jongwoo Son Lutz Ackermann
author_facet	Alexandra Schischko Nikolaos Kaplaneris Torben Rogge Giedre Sirvinskaite Jongwoo Son Lutz Ackermann
author_sort	Alexandra Schischko
title	Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
title_short	Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
title_full	Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
title_fullStr	Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
title_full_unstemmed	Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
title_sort	late-stage peptide c–h alkylation for bioorthogonal c–h activation featuring solid phase peptide synthesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d0672b6c73c4b54bd92fda2d14eeb00
work_keys_str_mv	AT alexandraschischko latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis AT nikolaoskaplaneris latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis AT torbenrogge latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis AT giedresirvinskaite latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis AT jongwooson latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis AT lutzackermann latestagepeptidechalkylationforbioorthogonalchactivationfeaturingsolidphasepeptidesynthesis
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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

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