Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study

Purpose To retrospectively compare the efficacy and safety of surgical resection (SR) and thermal ablation for the treatment of adrenal metastases. Methods From January 2008 to December 2018, 133 patients with adrenal metastases who underwent SR (n = 76) or thermal ablation (n = 57) were enrolled. T...

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Autores principales:	Lin Xie, Han Qi, Fei Cao, Lujun Shen, Shuanggang Chen, Ying Wu, Tao Huang, Ze Song, Weijun Fan
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	adrenal metastases surgical resection thermal ablation complications local progression-free survival Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/0d0695cb7b1b4bfcab6e6588905058fa
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spelling	oai:doaj.org-article:0d0695cb7b1b4bfcab6e6588905058fa2021-11-04T15:00:41ZComparison between surgery and thermal ablation for adrenal metastases: a retrospective study0265-67361464-515710.1080/02656736.2021.1993356https://doaj.org/article/0d0695cb7b1b4bfcab6e6588905058fa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.1993356https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Purpose To retrospectively compare the efficacy and safety of surgical resection (SR) and thermal ablation for the treatment of adrenal metastases. Methods From January 2008 to December 2018, 133 patients with adrenal metastases who underwent SR (n = 76) or thermal ablation (n = 57) were enrolled. The mean tumor size was 58.00 ± 10.65 mm (22-80 mm) in the SR group and 58.03 ± 12.76 mm (34–89 mm) in the thermal ablation group. Local progression-free survival (LPFS) and safety were compared between the two groups using the Kaplan–Meier method and log-rank tests. Cox proportional hazard regression models were used to evaluate the prognostic factors of LPFS. Complications, hospitalization days, and blood loss were also assessed. Results The median follow-up was 29.0 months (range, 20.4–37.6 months). No treatment-related mortality was observed. The 1-, 3- and 5-year LPFS rates were 74.0%, 62.8%, and 31.4% in the SR group and 72.8%, 68.7%, and 51.5% in the ablation group, with the median LPFS of 41.5 months (95% CI: 9.3–23.4 months) vs. 47.9 months (95% CI 20.6–75.8 months), respectively (p = 0.784). Tumor size ≥3 cm was the only significant risk factor for LPFS (p = 0.031). The ablation group was superior to the SR group with a lower major complication rate (4.1% vs. 14.5%, p = 0.03), less blood loss (1 ml vs. 100 ml, p < 0.001), and a shorter hospital stay (2 d vs. 6 d, p < 0.001). Conclusion Thermal ablation provided a similar LPFS and less comorbidities than SR, indicating that it is an effective and safe treatment for adrenal metastases.Lin XieHan QiFei CaoLujun ShenShuanggang ChenYing WuTao HuangZe SongWeijun FanTaylor & Francis Grouparticleadrenal metastasessurgical resectionthermal ablationcomplicationslocal progression-free survivalMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1541-1547 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrenal metastases surgical resection thermal ablation complications local progression-free survival Medical technology R855-855.5
spellingShingle	adrenal metastases surgical resection thermal ablation complications local progression-free survival Medical technology R855-855.5 Lin Xie Han Qi Fei Cao Lujun Shen Shuanggang Chen Ying Wu Tao Huang Ze Song Weijun Fan Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
description	Purpose To retrospectively compare the efficacy and safety of surgical resection (SR) and thermal ablation for the treatment of adrenal metastases. Methods From January 2008 to December 2018, 133 patients with adrenal metastases who underwent SR (n = 76) or thermal ablation (n = 57) were enrolled. The mean tumor size was 58.00 ± 10.65 mm (22-80 mm) in the SR group and 58.03 ± 12.76 mm (34–89 mm) in the thermal ablation group. Local progression-free survival (LPFS) and safety were compared between the two groups using the Kaplan–Meier method and log-rank tests. Cox proportional hazard regression models were used to evaluate the prognostic factors of LPFS. Complications, hospitalization days, and blood loss were also assessed. Results The median follow-up was 29.0 months (range, 20.4–37.6 months). No treatment-related mortality was observed. The 1-, 3- and 5-year LPFS rates were 74.0%, 62.8%, and 31.4% in the SR group and 72.8%, 68.7%, and 51.5% in the ablation group, with the median LPFS of 41.5 months (95% CI: 9.3–23.4 months) vs. 47.9 months (95% CI 20.6–75.8 months), respectively (p = 0.784). Tumor size ≥3 cm was the only significant risk factor for LPFS (p = 0.031). The ablation group was superior to the SR group with a lower major complication rate (4.1% vs. 14.5%, p = 0.03), less blood loss (1 ml vs. 100 ml, p < 0.001), and a shorter hospital stay (2 d vs. 6 d, p < 0.001). Conclusion Thermal ablation provided a similar LPFS and less comorbidities than SR, indicating that it is an effective and safe treatment for adrenal metastases.
format	article
author	Lin Xie Han Qi Fei Cao Lujun Shen Shuanggang Chen Ying Wu Tao Huang Ze Song Weijun Fan
author_facet	Lin Xie Han Qi Fei Cao Lujun Shen Shuanggang Chen Ying Wu Tao Huang Ze Song Weijun Fan
author_sort	Lin Xie
title	Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
title_short	Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
title_full	Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
title_fullStr	Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
title_full_unstemmed	Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
title_sort	comparison between surgery and thermal ablation for adrenal metastases: a retrospective study
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/0d0695cb7b1b4bfcab6e6588905058fa
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Comparison between surgery and thermal ablation for adrenal metastases: a retrospective study

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