Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease

Abstract Parkinson’s disease (PD) is a progressive neurological disorder characterised by motor and non-motor deficits. Repetitive transcranial magnetic stimulation (rTMS) over the bilateral primary motor cortex at a high frequency (5 Hz or higher) is reported to be a potential treatment of PD. We a...

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Autores principales:	Ken-ichi Okada, Mizuki Takahira, Tomoo Mano, Taichi Uga, Kuni Konaka, Koichi Hosomi, Youichi Saitoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d0f4de864294342aa8f746e5195fca5
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spelling	oai:doaj.org-article:0d0f4de864294342aa8f746e5195fca52021-12-02T13:57:25ZConcomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease10.1038/s41598-021-81795-32045-2322https://doaj.org/article/0d0f4de864294342aa8f746e5195fca52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81795-3https://doaj.org/toc/2045-2322Abstract Parkinson’s disease (PD) is a progressive neurological disorder characterised by motor and non-motor deficits. Repetitive transcranial magnetic stimulation (rTMS) over the bilateral primary motor cortex at a high frequency (5 Hz or higher) is reported to be a potential treatment of PD. We aimed to assess the effect of rTMS on eye movement control in patients with PD in their ‘on’ state. We enrolled 14 patients with PD and assessed motor symptoms (Movement Disorder Society-Sponsored Unified Parkinson’s Disease Rating Scale; MDS-UPDRS) and eye movement performances (visually guided saccades, volitional anti-saccades, and small involuntary saccades during fixation) at baseline and after administering bilateral 10 Hz rTMS on leg region of the motor cortex. We confirmed that rTMS improved the MDS-UPDRS motor scores and found that rTMS improved the anti-saccade success rate, which requires adequate inhibition of the reflexive response. The improvement in anti-saccade success rate was correlated with that of the postural instability gait difficulty (PIGD) sub-scores of MDS-UPDRS and lower baseline Japanese version of the Montreal Cognitive Assessment scores. This result is consistent with previous findings that PIGD and inhibitory control deficits share common brain dysfunctions in PD. rTMS may alleviate dysfunctions of that circuit and have a clinical effect.Ken-ichi OkadaMizuki TakahiraTomoo ManoTaichi UgaKuni KonakaKoichi HosomiYouichi SaitohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ken-ichi Okada Mizuki Takahira Tomoo Mano Taichi Uga Kuni Konaka Koichi Hosomi Youichi Saitoh Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
description	Abstract Parkinson’s disease (PD) is a progressive neurological disorder characterised by motor and non-motor deficits. Repetitive transcranial magnetic stimulation (rTMS) over the bilateral primary motor cortex at a high frequency (5 Hz or higher) is reported to be a potential treatment of PD. We aimed to assess the effect of rTMS on eye movement control in patients with PD in their ‘on’ state. We enrolled 14 patients with PD and assessed motor symptoms (Movement Disorder Society-Sponsored Unified Parkinson’s Disease Rating Scale; MDS-UPDRS) and eye movement performances (visually guided saccades, volitional anti-saccades, and small involuntary saccades during fixation) at baseline and after administering bilateral 10 Hz rTMS on leg region of the motor cortex. We confirmed that rTMS improved the MDS-UPDRS motor scores and found that rTMS improved the anti-saccade success rate, which requires adequate inhibition of the reflexive response. The improvement in anti-saccade success rate was correlated with that of the postural instability gait difficulty (PIGD) sub-scores of MDS-UPDRS and lower baseline Japanese version of the Montreal Cognitive Assessment scores. This result is consistent with previous findings that PIGD and inhibitory control deficits share common brain dysfunctions in PD. rTMS may alleviate dysfunctions of that circuit and have a clinical effect.
format	article
author	Ken-ichi Okada Mizuki Takahira Tomoo Mano Taichi Uga Kuni Konaka Koichi Hosomi Youichi Saitoh
author_facet	Ken-ichi Okada Mizuki Takahira Tomoo Mano Taichi Uga Kuni Konaka Koichi Hosomi Youichi Saitoh
author_sort	Ken-ichi Okada
title	Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
title_short	Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
title_full	Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
title_fullStr	Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
title_full_unstemmed	Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease
title_sort	concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rtms treatment for parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d0f4de864294342aa8f746e5195fca5
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Concomitant improvement in anti-saccade success rate and postural instability gait difficulty after rTMS treatment for Parkinson’s disease

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