Protein corona: a new approach for nanomedicine design

Van Hong Nguyen, Beom-Jin Lee Department of Pharmacy, Bioavailability Control Laboratory, College of Pharmacy, Ajou University, Suwon, Republic of Korea Abstract: After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the &...

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Autores principales:	Nguyen VH, Lee BJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	protein-nanoparticle interaction protein corona exchange of adsorbed protein toxicity reduction predictive modeling targeting drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0d1530b40d4b4233932d0897f61d1a45
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spelling	oai:doaj.org-article:0d1530b40d4b4233932d0897f61d1a452021-12-02T05:38:24ZProtein corona: a new approach for nanomedicine design1178-2013https://doaj.org/article/0d1530b40d4b4233932d0897f61d1a452017-04-01T00:00:00Zhttps://www.dovepress.com/protein-corona-a-new-approach-for-nanomedicine-design-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Van Hong Nguyen, Beom-Jin Lee Department of Pharmacy, Bioavailability Control Laboratory, College of Pharmacy, Ajou University, Suwon, Republic of Korea Abstract: After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly based on protein corona fingerprints of NPs are more highly accurate than the models solely set up from NP properties. Based on these models, effectiveness as well as the toxicity of NPs can be predicted without in vivo tests, while novel cell receptors could be identified from prominent proteins which play important key roles in the models. The ungoverned protein adsorption onto NPs may have generally negative effects such as rapid clearance from the bloodstream, hindrance of targeting capacity, and induction of toxicity. In contrast, controlling protein adsorption by modifying NPs with diverse functional proteins or tailoring appropriate NPs which favor selective endogenous peptides and proteins will bring promising therapeutic benefits in drug delivery and targeted cancer treatment. Keywords: protein-nanoparticle interaction, protein corona, exchange of adsorbed protein, toxicity reduction, predictive modeling, targeting drug deliveryNguyen VHLee BJDove Medical Pressarticleprotein-nanoparticle interactionprotein coronaexchange of adsorbed proteintoxicity reductionpredictive modelingtargeting drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3137-3151 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	protein-nanoparticle interaction protein corona exchange of adsorbed protein toxicity reduction predictive modeling targeting drug delivery Medicine (General) R5-920
spellingShingle	protein-nanoparticle interaction protein corona exchange of adsorbed protein toxicity reduction predictive modeling targeting drug delivery Medicine (General) R5-920 Nguyen VH Lee BJ Protein corona: a new approach for nanomedicine design
description	Van Hong Nguyen, Beom-Jin Lee Department of Pharmacy, Bioavailability Control Laboratory, College of Pharmacy, Ajou University, Suwon, Republic of Korea Abstract: After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly based on protein corona fingerprints of NPs are more highly accurate than the models solely set up from NP properties. Based on these models, effectiveness as well as the toxicity of NPs can be predicted without in vivo tests, while novel cell receptors could be identified from prominent proteins which play important key roles in the models. The ungoverned protein adsorption onto NPs may have generally negative effects such as rapid clearance from the bloodstream, hindrance of targeting capacity, and induction of toxicity. In contrast, controlling protein adsorption by modifying NPs with diverse functional proteins or tailoring appropriate NPs which favor selective endogenous peptides and proteins will bring promising therapeutic benefits in drug delivery and targeted cancer treatment. Keywords: protein-nanoparticle interaction, protein corona, exchange of adsorbed protein, toxicity reduction, predictive modeling, targeting drug delivery
format	article
author	Nguyen VH Lee BJ
author_facet	Nguyen VH Lee BJ
author_sort	Nguyen VH
title	Protein corona: a new approach for nanomedicine design
title_short	Protein corona: a new approach for nanomedicine design
title_full	Protein corona: a new approach for nanomedicine design
title_fullStr	Protein corona: a new approach for nanomedicine design
title_full_unstemmed	Protein corona: a new approach for nanomedicine design
title_sort	protein corona: a new approach for nanomedicine design
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0d1530b40d4b4233932d0897f61d1a45
work_keys_str_mv	AT nguyenvh proteincoronaanewapproachfornanomedicinedesign AT leebj proteincoronaanewapproachfornanomedicinedesign
_version_	1718400275861995520

Protein corona: a new approach for nanomedicine design

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