Sarcopenia and impairment in cognitive and physical performance
Magdalena I Tolea,1 James E Galvin1–3 1Alzheimer’s Disease Center, Department of Neurology, 2Department of Psychiatry, 3Department of Population Health, New York University School of Medicine, New York, NY, USA Background: Whether older adults with sarcopenia who under...
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Dove Medical Press
2015
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oai:doaj.org-article:0d1713547b4b444e8f52f493253970d82021-12-02T04:39:01ZSarcopenia and impairment in cognitive and physical performance1178-1998https://doaj.org/article/0d1713547b4b444e8f52f493253970d82015-03-01T00:00:00Zhttps://www.dovepress.com/sarcopenia-and-impairment-in-cognitive-andnbspphysical-performance-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Magdalena I Tolea,1 James E Galvin1–3 1Alzheimer’s Disease Center, Department of Neurology, 2Department of Psychiatry, 3Department of Population Health, New York University School of Medicine, New York, NY, USA Background: Whether older adults with sarcopenia who underperform controls on tests of physical performance and cognition also have a higher likelihood of combined cognitive-physical impairment is not clear. We assessed the impact of sarcopenia on impairment in both aspects of functionality and the relative contribution of its components, muscle mass and strength.Methods: Two hundred and twenty-three community-dwelling adults aged 40 years and older (mean age =68.1±10.6 years; 65% female) were recruited and underwent physical functionality, anthropometry, and cognitive testing. Participants with low muscle mass were categorized as pre-sarcopenic; those with low muscle mass and muscle strength as sarcopenic; those with higher muscle mass and low muscle strength only were categorized as non-sarcopenic and were compared on risk of cognitive impairment (Montreal Cognitive Assessment <26; Ascertaining Dementia 8 ≥2), physical impairment (Mini Physical Performance Test <12), both, or neither by ordinal logistic regression. Results: Compared to controls, those with sarcopenia were six times more likely to have combined cognitive impairment/physical impairment with a fully adjusted model showing a three-fold increased odds ratio. The results were consistent across different measures of global cognition (odds ratio =3.46, 95% confidence interval =1.07–11.45 for the Montreal Cognitive Assessment; odds ratio =3.61, 95% confidence interval =1.11–11.72 for Ascertaining Dementia 8). Pre-sarcopenic participants were not different from controls. The effect of sarcopenia on cognition is related to low muscle strength rather than low muscle mass. Conclusion: Individuals with sarcopenia are not only more likely to have single but also to have dual impairment in cognitive and physical function. Interventions designed to prevent sarcopenia and improve muscle strength may help reduce the burden of cognitive and physical impairments of functionality in community-dwelling seniors. Keywords: cross-sectional, muscle strength, muscle mass, physical impairment, cognitive impairment, older adultsTolea MIGalvin JEDove Medical Pressarticlesarcopeniaphysical impairmentcognitive impairmentGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 663-671 (2015) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
sarcopenia physical impairment cognitive impairment Geriatrics RC952-954.6 |
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sarcopenia physical impairment cognitive impairment Geriatrics RC952-954.6 Tolea MI Galvin JE Sarcopenia and impairment in cognitive and physical performance |
| description |
Magdalena I Tolea,1 James E Galvin1–3 1Alzheimer’s Disease Center, Department of Neurology, 2Department of Psychiatry, 3Department of Population Health, New York University School of Medicine, New York, NY, USA Background: Whether older adults with sarcopenia who underperform controls on tests of physical performance and cognition also have a higher likelihood of combined cognitive-physical impairment is not clear. We assessed the impact of sarcopenia on impairment in both aspects of functionality and the relative contribution of its components, muscle mass and strength.Methods: Two hundred and twenty-three community-dwelling adults aged 40 years and older (mean age =68.1±10.6 years; 65% female) were recruited and underwent physical functionality, anthropometry, and cognitive testing. Participants with low muscle mass were categorized as pre-sarcopenic; those with low muscle mass and muscle strength as sarcopenic; those with higher muscle mass and low muscle strength only were categorized as non-sarcopenic and were compared on risk of cognitive impairment (Montreal Cognitive Assessment <26; Ascertaining Dementia 8 ≥2), physical impairment (Mini Physical Performance Test <12), both, or neither by ordinal logistic regression. Results: Compared to controls, those with sarcopenia were six times more likely to have combined cognitive impairment/physical impairment with a fully adjusted model showing a three-fold increased odds ratio. The results were consistent across different measures of global cognition (odds ratio =3.46, 95% confidence interval =1.07–11.45 for the Montreal Cognitive Assessment; odds ratio =3.61, 95% confidence interval =1.11–11.72 for Ascertaining Dementia 8). Pre-sarcopenic participants were not different from controls. The effect of sarcopenia on cognition is related to low muscle strength rather than low muscle mass. Conclusion: Individuals with sarcopenia are not only more likely to have single but also to have dual impairment in cognitive and physical function. Interventions designed to prevent sarcopenia and improve muscle strength may help reduce the burden of cognitive and physical impairments of functionality in community-dwelling seniors. Keywords: cross-sectional, muscle strength, muscle mass, physical impairment, cognitive impairment, older adults |
| format |
article |
| author |
Tolea MI Galvin JE |
| author_facet |
Tolea MI Galvin JE |
| author_sort |
Tolea MI |
| title |
Sarcopenia and impairment in cognitive and physical performance |
| title_short |
Sarcopenia and impairment in cognitive and physical performance |
| title_full |
Sarcopenia and impairment in cognitive and physical performance |
| title_fullStr |
Sarcopenia and impairment in cognitive and physical performance |
| title_full_unstemmed |
Sarcopenia and impairment in cognitive and physical performance |
| title_sort |
sarcopenia and impairment in cognitive and physical performance |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/0d1713547b4b444e8f52f493253970d8 |
| work_keys_str_mv |
AT toleami sarcopeniaandimpairmentincognitiveandnbspphysicalperformance AT galvinje sarcopeniaandimpairmentincognitiveandnbspphysicalperformance |
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1718401108965064704 |