TH17, TH22 and Treg cells are enriched in the healthy human cecum.

There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in...

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Autores principales:	Martin J Wolff, Jacqueline M Leung, Michael Davenport, Michael A Poles, Ilseung Cho, P'ng Loke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d1c213c6deb419abc63e745fbe7ac1d
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spelling	oai:doaj.org-article:0d1c213c6deb419abc63e745fbe7ac1d2021-11-18T07:11:47ZTH17, TH22 and Treg cells are enriched in the healthy human cecum.1932-620310.1371/journal.pone.0041373https://doaj.org/article/0d1c213c6deb419abc63e745fbe7ac1d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829946/?tool=EBIhttps://doaj.org/toc/1932-6203There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment.Martin J WolffJacqueline M LeungMichael DavenportMichael A PolesIlseung ChoP'ng LokePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41373 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin J Wolff Jacqueline M Leung Michael Davenport Michael A Poles Ilseung Cho P'ng Loke TH17, TH22 and Treg cells are enriched in the healthy human cecum.
description	There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment.
format	article
author	Martin J Wolff Jacqueline M Leung Michael Davenport Michael A Poles Ilseung Cho P'ng Loke
author_facet	Martin J Wolff Jacqueline M Leung Michael Davenport Michael A Poles Ilseung Cho P'ng Loke
author_sort	Martin J Wolff
title	TH17, TH22 and Treg cells are enriched in the healthy human cecum.
title_short	TH17, TH22 and Treg cells are enriched in the healthy human cecum.
title_full	TH17, TH22 and Treg cells are enriched in the healthy human cecum.
title_fullStr	TH17, TH22 and Treg cells are enriched in the healthy human cecum.
title_full_unstemmed	TH17, TH22 and Treg cells are enriched in the healthy human cecum.
title_sort	th17, th22 and treg cells are enriched in the healthy human cecum.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0d1c213c6deb419abc63e745fbe7ac1d
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TH17, TH22 and Treg cells are enriched in the healthy human cecum.

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