Spinal cord injury causes chronic bone marrow failure

Spinal cord injury causes chronic bone marrow failure

Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and d...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/0d1de6f876b2431485cb553f43443b20
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0d1de6f876b2431485cb553f43443b20
record_format dspace
spelling oai:doaj.org-article:0d1de6f876b2431485cb553f43443b202021-12-02T17:55:10ZSpinal cord injury causes chronic bone marrow failure10.1038/s41467-020-17564-z2041-1723https://doaj.org/article/0d1de6f876b2431485cb553f43443b202020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17564-zhttps://doaj.org/toc/2041-1723Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.Randall S. CarpenterJessica M. MarbourgFaith H. BrennanKatherine A. MifflinJodie C. E. HallRoselyn R. JiangXiaokui M. MoMalith KarunasiriMatthew H. BurkeAdrienne M. DorrancePhillip G. PopovichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Randall S. Carpenter
Jessica M. Marbourg
Faith H. Brennan
Katherine A. Mifflin
Jodie C. E. Hall
Roselyn R. Jiang
Xiaokui M. Mo
Malith Karunasiri
Matthew H. Burke
Adrienne M. Dorrance
Phillip G. Popovich
Spinal cord injury causes chronic bone marrow failure
description Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.
format article
author Randall S. Carpenter
Jessica M. Marbourg
Faith H. Brennan
Katherine A. Mifflin
Jodie C. E. Hall
Roselyn R. Jiang
Xiaokui M. Mo
Malith Karunasiri
Matthew H. Burke
Adrienne M. Dorrance
Phillip G. Popovich
author_facet Randall S. Carpenter
Jessica M. Marbourg
Faith H. Brennan
Katherine A. Mifflin
Jodie C. E. Hall
Roselyn R. Jiang
Xiaokui M. Mo
Malith Karunasiri
Matthew H. Burke
Adrienne M. Dorrance
Phillip G. Popovich
author_sort Randall S. Carpenter
title Spinal cord injury causes chronic bone marrow failure
title_short Spinal cord injury causes chronic bone marrow failure
title_full Spinal cord injury causes chronic bone marrow failure
title_fullStr Spinal cord injury causes chronic bone marrow failure
title_full_unstemmed Spinal cord injury causes chronic bone marrow failure
title_sort spinal cord injury causes chronic bone marrow failure
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0d1de6f876b2431485cb553f43443b20
work_keys_str_mv AT randallscarpenter spinalcordinjurycauseschronicbonemarrowfailure
AT jessicammarbourg spinalcordinjurycauseschronicbonemarrowfailure
AT faithhbrennan spinalcordinjurycauseschronicbonemarrowfailure
AT katherineamifflin spinalcordinjurycauseschronicbonemarrowfailure
AT jodiecehall spinalcordinjurycauseschronicbonemarrowfailure
AT roselynrjiang spinalcordinjurycauseschronicbonemarrowfailure
AT xiaokuimmo spinalcordinjurycauseschronicbonemarrowfailure
AT malithkarunasiri spinalcordinjurycauseschronicbonemarrowfailure
AT matthewhburke spinalcordinjurycauseschronicbonemarrowfailure
AT adriennemdorrance spinalcordinjurycauseschronicbonemarrowfailure
AT phillipgpopovich spinalcordinjurycauseschronicbonemarrowfailure
_version_ 1718379087691513856

Ejemplares similares