Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
High-throughput monitoring of neurotransmitter release at single-vesicle resolution remains a challenge. Here, the authors present a silicon-based electrode array with 1024 on-chip electrodes that measures neurochemical signal in 0.1 millisecond intervals to capture the modulation of exocytosis due...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/0d1edee812d941afaf293008f87847b5 |
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| Sumario: | High-throughput monitoring of neurotransmitter release at single-vesicle resolution remains a challenge. Here, the authors present a silicon-based electrode array with 1024 on-chip electrodes that measures neurochemical signal in 0.1 millisecond intervals to capture the modulation of exocytosis due to Parkinson’s disease treatment within 30 total minutes of recording. |
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