Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array

High-throughput monitoring of neurotransmitter release at single-vesicle resolution remains a challenge. Here, the authors present a silicon-based electrode array with 1024 on-chip electrodes that measures neurochemical signal in 0.1 millisecond intervals to capture the modulation of exocytosis due...

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Autores principales:	Kevin A. White, Brian N. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d1edee812d941afaf293008f87847b5
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spelling	oai:doaj.org-article:0d1edee812d941afaf293008f87847b52021-12-02T13:51:03ZQuantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array10.1038/s41467-020-20267-02041-1723https://doaj.org/article/0d1edee812d941afaf293008f87847b52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20267-0https://doaj.org/toc/2041-1723High-throughput monitoring of neurotransmitter release at single-vesicle resolution remains a challenge. Here, the authors present a silicon-based electrode array with 1024 on-chip electrodes that measures neurochemical signal in 0.1 millisecond intervals to capture the modulation of exocytosis due to Parkinson’s disease treatment within 30 total minutes of recording.Kevin A. WhiteBrian N. KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin A. White Brian N. Kim Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
description	High-throughput monitoring of neurotransmitter release at single-vesicle resolution remains a challenge. Here, the authors present a silicon-based electrode array with 1024 on-chip electrodes that measures neurochemical signal in 0.1 millisecond intervals to capture the modulation of exocytosis due to Parkinson’s disease treatment within 30 total minutes of recording.
format	article
author	Kevin A. White Brian N. Kim
author_facet	Kevin A. White Brian N. Kim
author_sort	Kevin A. White
title	Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
title_short	Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
title_full	Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
title_fullStr	Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
title_full_unstemmed	Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
title_sort	quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d1edee812d941afaf293008f87847b5
work_keys_str_mv	AT kevinawhite quantifyingneurotransmittersecretionatsinglevesicleresolutionusinghighdensitycomplementarymetaloxidesemiconductorelectrodearray AT briannkim quantifyingneurotransmittersecretionatsinglevesicleresolutionusinghighdensitycomplementarymetaloxidesemiconductorelectrodearray
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Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array

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