Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment

IL-33 is a pro-inflammatory cytokine with a role in colorectal cancer. Here, the authors show that circulating tumour-derived sST2, an IL-33 decoy receptor, delayed the growth and progression of colorectal cancer cells by inhibiting Th1/Th2 polarization, macrophage infiltration and angiogenesis.

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Autores principales:	Miho Akimoto, Riruke Maruyama, Hiroyuki Takamaru, Takahiro Ochiya, Keizo Takenaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d1f25d196c74db7ba33675314d0a9e1
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spelling	oai:doaj.org-article:0d1f25d196c74db7ba33675314d0a9e12021-12-02T17:32:53ZSoluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment10.1038/ncomms135892041-1723https://doaj.org/article/0d1f25d196c74db7ba33675314d0a9e12016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13589https://doaj.org/toc/2041-1723IL-33 is a pro-inflammatory cytokine with a role in colorectal cancer. Here, the authors show that circulating tumour-derived sST2, an IL-33 decoy receptor, delayed the growth and progression of colorectal cancer cells by inhibiting Th1/Th2 polarization, macrophage infiltration and angiogenesis.Miho AkimotoRiruke MaruyamaHiroyuki TakamaruTakahiro OchiyaKeizo TakenagaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miho Akimoto Riruke Maruyama Hiroyuki Takamaru Takahiro Ochiya Keizo Takenaga Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
description	IL-33 is a pro-inflammatory cytokine with a role in colorectal cancer. Here, the authors show that circulating tumour-derived sST2, an IL-33 decoy receptor, delayed the growth and progression of colorectal cancer cells by inhibiting Th1/Th2 polarization, macrophage infiltration and angiogenesis.
format	article
author	Miho Akimoto Riruke Maruyama Hiroyuki Takamaru Takahiro Ochiya Keizo Takenaga
author_facet	Miho Akimoto Riruke Maruyama Hiroyuki Takamaru Takahiro Ochiya Keizo Takenaga
author_sort	Miho Akimoto
title	Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
title_short	Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
title_full	Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
title_fullStr	Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
title_full_unstemmed	Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
title_sort	soluble il-33 receptor sst2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0d1f25d196c74db7ba33675314d0a9e1
work_keys_str_mv	AT mihoakimoto solubleil33receptorsst2inhibitscolorectalcancermalignantgrowthbymodifyingthetumourmicroenvironment AT rirukemaruyama solubleil33receptorsst2inhibitscolorectalcancermalignantgrowthbymodifyingthetumourmicroenvironment AT hiroyukitakamaru solubleil33receptorsst2inhibitscolorectalcancermalignantgrowthbymodifyingthetumourmicroenvironment AT takahiroochiya solubleil33receptorsst2inhibitscolorectalcancermalignantgrowthbymodifyingthetumourmicroenvironment AT keizotakenaga solubleil33receptorsst2inhibitscolorectalcancermalignantgrowthbymodifyingthetumourmicroenvironment
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Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment

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