Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.

Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.

Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic cancer and represent an attractive target. Direct targeting of the predominant KRAS pathways have been challenging and research into therapeut...

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Autores principales: Hua Zhong, Cesar Sanchez, Dirk Spitzer, Stacy Plambeck-Suess, Jesse Gibbs, Williams G Hawkins, David Denardo, Feng Gao, Robert A Pufahl, Albert C Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-Gillam
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0d201c298dc440a981449a4b27ac0bee
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