Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

Background. There is no effective therapy for silicosis, and Dahuang Zhechong pill (DHZCP), an ancient Chinese medicine prescription, may have a therapeutic effect on silicosis. This study aims to verify the efficacy and safety of DHZCP in silicosis. Methods. This is a randomized controlled clinical...

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Autores principales:	Wu-Yi-Nuo Tang, Jing-Tao Liang, Ju Wu, Li Liu, Ming-Zhang Lu, Xiao-Yan He, Li-Juan Wu, Huan-Yu Jiang, Fei Wang, Xiao Meng, Shun-Pin Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/0d22b6dcaee547b6b94cee6218d7580a
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spelling	oai:doaj.org-article:0d22b6dcaee547b6b94cee6218d7580a2021-11-29T00:56:55ZEfficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial1741-428810.1155/2021/4354054https://doaj.org/article/0d22b6dcaee547b6b94cee6218d7580a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4354054https://doaj.org/toc/1741-4288Background. There is no effective therapy for silicosis, and Dahuang Zhechong pill (DHZCP), an ancient Chinese medicine prescription, may have a therapeutic effect on silicosis. This study aims to verify the efficacy and safety of DHZCP in silicosis. Methods. This is a randomized controlled clinical trial done at Panzhihua Second People’s Hospital (Panzhihua City, Sichuan Province, China). Participants diagnosed with silicosis were recruited and randomized to the conventional treatment group (CG) or DHZCP combined with the conventional treatment group (DG). Forced vital capacity % predicted (FVC%), diffusing capacity of the lung for carbon monoxide % predicted (DLCO%), six-minute walk distance (6MWD), peripheral oxygen (SpO2), King’s Brief Interstitial Lung Disease Questionnaire (K-BILD), and safety outcomes were measured at baseline and 9 weeks. Results. Fifty-six participants (28 in each group) completed the study, and 53 of them (26 in DG and 27 in CG) completed pulmonary function. At 9 weeks, compared with no DHZCP, DHZCP treatment was associated with significant improvements in FVC% (mean ± SD, 95%CI) (8.2 ± 3.9, 0.3 to 16.0), DLCO% (8.6 ± 3.5, 1.5 to 15.7), SpO2 (3.8 ± 0.7, 2.3 to 5.2), and K-BILD total score (6.0 ± 2.3, 1.4 to 10.7). And, there were no statistical differences of safety outcomes between the two groups. Eight patients accepting DHZCP developed mild diarrhea during the first week, which subsequently resolved on its own. Conclusion. DHZCP could improve the pulmonary function, the quality of life, and the exercise capacity of silicosis patients.Wu-Yi-Nuo TangJing-Tao LiangJu WuLi LiuMing-Zhang LuXiao-Yan HeLi-Juan WuHuan-Yu JiangFei WangXiao MengShun-Pin LiHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Wu-Yi-Nuo Tang Jing-Tao Liang Ju Wu Li Liu Ming-Zhang Lu Xiao-Yan He Li-Juan Wu Huan-Yu Jiang Fei Wang Xiao Meng Shun-Pin Li Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
description	Background. There is no effective therapy for silicosis, and Dahuang Zhechong pill (DHZCP), an ancient Chinese medicine prescription, may have a therapeutic effect on silicosis. This study aims to verify the efficacy and safety of DHZCP in silicosis. Methods. This is a randomized controlled clinical trial done at Panzhihua Second People’s Hospital (Panzhihua City, Sichuan Province, China). Participants diagnosed with silicosis were recruited and randomized to the conventional treatment group (CG) or DHZCP combined with the conventional treatment group (DG). Forced vital capacity % predicted (FVC%), diffusing capacity of the lung for carbon monoxide % predicted (DLCO%), six-minute walk distance (6MWD), peripheral oxygen (SpO2), King’s Brief Interstitial Lung Disease Questionnaire (K-BILD), and safety outcomes were measured at baseline and 9 weeks. Results. Fifty-six participants (28 in each group) completed the study, and 53 of them (26 in DG and 27 in CG) completed pulmonary function. At 9 weeks, compared with no DHZCP, DHZCP treatment was associated with significant improvements in FVC% (mean ± SD, 95%CI) (8.2 ± 3.9, 0.3 to 16.0), DLCO% (8.6 ± 3.5, 1.5 to 15.7), SpO2 (3.8 ± 0.7, 2.3 to 5.2), and K-BILD total score (6.0 ± 2.3, 1.4 to 10.7). And, there were no statistical differences of safety outcomes between the two groups. Eight patients accepting DHZCP developed mild diarrhea during the first week, which subsequently resolved on its own. Conclusion. DHZCP could improve the pulmonary function, the quality of life, and the exercise capacity of silicosis patients.
format	article
author	Wu-Yi-Nuo Tang Jing-Tao Liang Ju Wu Li Liu Ming-Zhang Lu Xiao-Yan He Li-Juan Wu Huan-Yu Jiang Fei Wang Xiao Meng Shun-Pin Li
author_facet	Wu-Yi-Nuo Tang Jing-Tao Liang Ju Wu Li Liu Ming-Zhang Lu Xiao-Yan He Li-Juan Wu Huan-Yu Jiang Fei Wang Xiao Meng Shun-Pin Li
author_sort	Wu-Yi-Nuo Tang
title	Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
title_short	Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
title_full	Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
title_fullStr	Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
title_full_unstemmed	Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial
title_sort	efficacy and safety of dahuang zhechong pill in silicosis: a randomized controlled trial
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/0d22b6dcaee547b6b94cee6218d7580a
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Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

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