The NCAN gene: schizophrenia susceptibility and cognitive dysfunction

Peirong Wang,1 Jun Cai,2 Jianliang Ni,1 Jiangtao Zhang,1 Wei Tang,3 Chen Zhang2 1Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 2Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 3Wenzhou Kangning H...

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Autores principales:	Wang P, Cai J, Ni J, Zhang J, Tang W, Zhang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	NCAN Schizophrenia Cognitive function Polymorphism eQTL Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0d2531319627486893a0129f500b4e26
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spelling	oai:doaj.org-article:0d2531319627486893a0129f500b4e262021-12-02T02:11:54ZThe NCAN gene: schizophrenia susceptibility and cognitive dysfunction1178-2021https://doaj.org/article/0d2531319627486893a0129f500b4e262016-11-01T00:00:00Zhttps://www.dovepress.com/the-ncan-gene-schizophrenia-susceptibility-and-cognitive-dysfunction-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Peirong Wang,1 Jun Cai,2 Jianliang Ni,1 Jiangtao Zhang,1 Wei Tang,3 Chen Zhang2 1Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 2Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 3Wenzhou Kangning Hospital, Wenzhou, Zhejiang, People’s Republic of China Background: Cognitive dysfunction has been recognized as a cardinal feature of schizophrenia. Elucidating the neurobiological substrates of cognitive dysfunction in schizophrenia would help identify the underlying mechanism of this disorder. The rs1064395 single nucleotide polymorphism, within the gene encoding neurocan (NCAN), is reported to be associated with schizophrenia in European populations and may influence brain structure in patients with schizophrenia.Methods: In this study, we aimed to explore whether NCAN rs1064395 confers some risk for schizophrenia and cognitive dysfunction in Han Chinese. We recruited 681 patients with schizophrenia and 699 healthy subjects. Two hundred and fifty-four patients were evaluated according to Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).Results: There were no significant differences in genotype or allele distributions of the rs1064395 polymorphism between the schizophrenia and control groups. Patients showed significantly poorer performance than controls on immediate memory, visuospatial skill, language, attention, delayed memory, and total RBANS score. Patients with the A/A or A/G genotype of rs1064395 had lower scores of immediate memory, visuospatial skill, attention, and total RBANS score than those with the G/G genotype. We performed an expression quantitative trait loci analysis and observed a significant association between rs1064395 and NCAN expression in the frontal (P=0.0022, P=0.022 after Bonferroni correction) and cerebellar cortex (P=0.0032, P=0.032 after Bonferroni correction).Conclusion: Our findings indicate that this single nucleotide polymorphism may be a risk factor for cognitive dysfunction in patients with schizophrenia. Further investigations are warranted for validation purposes and to identify the precise mechanism by which rs1064395 influences cognitive performance in patients with schizophrenia. Keywords: NCAN, schizophrenia, cognitive function, polymorphism, eQTLWang PCai JNi JZhang JTang WZhang CDove Medical PressarticleNCANSchizophreniaCognitive functionPolymorphismeQTLNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2875-2883 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	NCAN Schizophrenia Cognitive function Polymorphism eQTL Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	NCAN Schizophrenia Cognitive function Polymorphism eQTL Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang P Cai J Ni J Zhang J Tang W Zhang C The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
description	Peirong Wang,1 Jun Cai,2 Jianliang Ni,1 Jiangtao Zhang,1 Wei Tang,3 Chen Zhang2 1Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 2Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 3Wenzhou Kangning Hospital, Wenzhou, Zhejiang, People’s Republic of China Background: Cognitive dysfunction has been recognized as a cardinal feature of schizophrenia. Elucidating the neurobiological substrates of cognitive dysfunction in schizophrenia would help identify the underlying mechanism of this disorder. The rs1064395 single nucleotide polymorphism, within the gene encoding neurocan (NCAN), is reported to be associated with schizophrenia in European populations and may influence brain structure in patients with schizophrenia.Methods: In this study, we aimed to explore whether NCAN rs1064395 confers some risk for schizophrenia and cognitive dysfunction in Han Chinese. We recruited 681 patients with schizophrenia and 699 healthy subjects. Two hundred and fifty-four patients were evaluated according to Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).Results: There were no significant differences in genotype or allele distributions of the rs1064395 polymorphism between the schizophrenia and control groups. Patients showed significantly poorer performance than controls on immediate memory, visuospatial skill, language, attention, delayed memory, and total RBANS score. Patients with the A/A or A/G genotype of rs1064395 had lower scores of immediate memory, visuospatial skill, attention, and total RBANS score than those with the G/G genotype. We performed an expression quantitative trait loci analysis and observed a significant association between rs1064395 and NCAN expression in the frontal (P=0.0022, P=0.022 after Bonferroni correction) and cerebellar cortex (P=0.0032, P=0.032 after Bonferroni correction).Conclusion: Our findings indicate that this single nucleotide polymorphism may be a risk factor for cognitive dysfunction in patients with schizophrenia. Further investigations are warranted for validation purposes and to identify the precise mechanism by which rs1064395 influences cognitive performance in patients with schizophrenia. Keywords: NCAN, schizophrenia, cognitive function, polymorphism, eQTL
format	article
author	Wang P Cai J Ni J Zhang J Tang W Zhang C
author_facet	Wang P Cai J Ni J Zhang J Tang W Zhang C
author_sort	Wang P
title	The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
title_short	The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
title_full	The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
title_fullStr	The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
title_full_unstemmed	The NCAN gene: schizophrenia susceptibility and cognitive dysfunction
title_sort	ncan gene: schizophrenia susceptibility and cognitive dysfunction
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0d2531319627486893a0129f500b4e26
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_version_	1718402571961368576

The NCAN gene: schizophrenia susceptibility and cognitive dysfunction

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