Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.

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Auteurs principaux:	Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba
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spelling	oai:doaj.org-article:0d25d8e1163b4f90ae02c9c439b13fba2021-12-02T13:57:55ZAtg4 proteolytic activity can be inhibited by Atg1 phosphorylation10.1038/s41467-017-00302-32041-1723https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00302-3https://doaj.org/toc/2041-1723The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.Jana Sánchez-WandelmerFranziska KriegenburgSabrina RohringerMartina SchuschnigRubén Gómez-SánchezBettina ZensSusana AbreuRalph HardenbergDavid HollensteinJieqiong GaoChristian UngermannSascha MartensClaudine KraftFulvio ReggioriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jana Sánchez-Wandelmer Franziska Kriegenburg Sabrina Rohringer Martina Schuschnig Rubén Gómez-Sánchez Bettina Zens Susana Abreu Ralph Hardenberg David Hollenstein Jieqiong Gao Christian Ungermann Sascha Martens Claudine Kraft Fulvio Reggiori Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
description	The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.
format	article
author	Jana Sánchez-Wandelmer Franziska Kriegenburg Sabrina Rohringer Martina Schuschnig Rubén Gómez-Sánchez Bettina Zens Susana Abreu Ralph Hardenberg David Hollenstein Jieqiong Gao Christian Ungermann Sascha Martens Claudine Kraft Fulvio Reggiori
author_facet	Jana Sánchez-Wandelmer Franziska Kriegenburg Sabrina Rohringer Martina Schuschnig Rubén Gómez-Sánchez Bettina Zens Susana Abreu Ralph Hardenberg David Hollenstein Jieqiong Gao Christian Ungermann Sascha Martens Claudine Kraft Fulvio Reggiori
author_sort	Jana Sánchez-Wandelmer
title	Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
title_short	Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
title_full	Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
title_fullStr	Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
title_full_unstemmed	Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
title_sort	atg4 proteolytic activity can be inhibited by atg1 phosphorylation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba
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Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

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