A core filamentation response network in Candida albicans is restricted to eight genes.
Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external...
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2013
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oai:doaj.org-article:0d265f525786479a80212d12b2d8226d2021-11-18T07:53:27ZA core filamentation response network in Candida albicans is restricted to eight genes.1932-620310.1371/journal.pone.0058613https://doaj.org/article/0d265f525786479a80212d12b2d8226d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516516/?tool=EBIhttps://doaj.org/toc/1932-6203Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external stimuli for morphogenesis we identified a set of eight genes with highly correlated expression patterns, forming a core filamentation response. This group of genes included ALS3, ECE1, HGT2, HWP1, IHD1 and RBT1 which are known or supposed to encode for cell- wall associated proteins as well as the Rac1 guanine nucleotide exchange factor encoding gene DCK1 and the unknown function open reading frame orf19.2457. The validity of network modeling was confirmed using a dataset of advanced complexity that describes the transcriptional response of C. albicans during epithelial invasion as well as comparing our results with other previously published transcriptome studies. Although the set of core filamentation response genes was quite small, several transcriptional regulators are involved in the control of their expression, depending on the environmental condition.Ronny MartinDaniela Albrecht-EckardtSascha BrunkeBernhard HubeKerstin HünnigerOliver KurzaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58613 (2013) |
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Medicine R Science Q Ronny Martin Daniela Albrecht-Eckardt Sascha Brunke Bernhard Hube Kerstin Hünniger Oliver Kurzai A core filamentation response network in Candida albicans is restricted to eight genes. |
description |
Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external stimuli for morphogenesis we identified a set of eight genes with highly correlated expression patterns, forming a core filamentation response. This group of genes included ALS3, ECE1, HGT2, HWP1, IHD1 and RBT1 which are known or supposed to encode for cell- wall associated proteins as well as the Rac1 guanine nucleotide exchange factor encoding gene DCK1 and the unknown function open reading frame orf19.2457. The validity of network modeling was confirmed using a dataset of advanced complexity that describes the transcriptional response of C. albicans during epithelial invasion as well as comparing our results with other previously published transcriptome studies. Although the set of core filamentation response genes was quite small, several transcriptional regulators are involved in the control of their expression, depending on the environmental condition. |
format |
article |
author |
Ronny Martin Daniela Albrecht-Eckardt Sascha Brunke Bernhard Hube Kerstin Hünniger Oliver Kurzai |
author_facet |
Ronny Martin Daniela Albrecht-Eckardt Sascha Brunke Bernhard Hube Kerstin Hünniger Oliver Kurzai |
author_sort |
Ronny Martin |
title |
A core filamentation response network in Candida albicans is restricted to eight genes. |
title_short |
A core filamentation response network in Candida albicans is restricted to eight genes. |
title_full |
A core filamentation response network in Candida albicans is restricted to eight genes. |
title_fullStr |
A core filamentation response network in Candida albicans is restricted to eight genes. |
title_full_unstemmed |
A core filamentation response network in Candida albicans is restricted to eight genes. |
title_sort |
core filamentation response network in candida albicans is restricted to eight genes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doaj.org/article/0d265f525786479a80212d12b2d8226d |
work_keys_str_mv |
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