A core filamentation response network in Candida albicans is restricted to eight genes.

Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external...

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Autores principales: Ronny Martin, Daniela Albrecht-Eckardt, Sascha Brunke, Bernhard Hube, Kerstin Hünniger, Oliver Kurzai
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/0d265f525786479a80212d12b2d8226d
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spelling oai:doaj.org-article:0d265f525786479a80212d12b2d8226d2021-11-18T07:53:27ZA core filamentation response network in Candida albicans is restricted to eight genes.1932-620310.1371/journal.pone.0058613https://doaj.org/article/0d265f525786479a80212d12b2d8226d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516516/?tool=EBIhttps://doaj.org/toc/1932-6203Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external stimuli for morphogenesis we identified a set of eight genes with highly correlated expression patterns, forming a core filamentation response. This group of genes included ALS3, ECE1, HGT2, HWP1, IHD1 and RBT1 which are known or supposed to encode for cell- wall associated proteins as well as the Rac1 guanine nucleotide exchange factor encoding gene DCK1 and the unknown function open reading frame orf19.2457. The validity of network modeling was confirmed using a dataset of advanced complexity that describes the transcriptional response of C. albicans during epithelial invasion as well as comparing our results with other previously published transcriptome studies. Although the set of core filamentation response genes was quite small, several transcriptional regulators are involved in the control of their expression, depending on the environmental condition.Ronny MartinDaniela Albrecht-EckardtSascha BrunkeBernhard HubeKerstin HünnigerOliver KurzaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58613 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ronny Martin
Daniela Albrecht-Eckardt
Sascha Brunke
Bernhard Hube
Kerstin Hünniger
Oliver Kurzai
A core filamentation response network in Candida albicans is restricted to eight genes.
description Although morphological plasticity is a central virulence trait of Candida albicans, the number of filament-associated genes and the interplay of mechanisms regulating their expression remain unknown. By correlation-based network modeling of the transcriptional response to different defined external stimuli for morphogenesis we identified a set of eight genes with highly correlated expression patterns, forming a core filamentation response. This group of genes included ALS3, ECE1, HGT2, HWP1, IHD1 and RBT1 which are known or supposed to encode for cell- wall associated proteins as well as the Rac1 guanine nucleotide exchange factor encoding gene DCK1 and the unknown function open reading frame orf19.2457. The validity of network modeling was confirmed using a dataset of advanced complexity that describes the transcriptional response of C. albicans during epithelial invasion as well as comparing our results with other previously published transcriptome studies. Although the set of core filamentation response genes was quite small, several transcriptional regulators are involved in the control of their expression, depending on the environmental condition.
format article
author Ronny Martin
Daniela Albrecht-Eckardt
Sascha Brunke
Bernhard Hube
Kerstin Hünniger
Oliver Kurzai
author_facet Ronny Martin
Daniela Albrecht-Eckardt
Sascha Brunke
Bernhard Hube
Kerstin Hünniger
Oliver Kurzai
author_sort Ronny Martin
title A core filamentation response network in Candida albicans is restricted to eight genes.
title_short A core filamentation response network in Candida albicans is restricted to eight genes.
title_full A core filamentation response network in Candida albicans is restricted to eight genes.
title_fullStr A core filamentation response network in Candida albicans is restricted to eight genes.
title_full_unstemmed A core filamentation response network in Candida albicans is restricted to eight genes.
title_sort core filamentation response network in candida albicans is restricted to eight genes.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/0d265f525786479a80212d12b2d8226d
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