Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice

ABSTRACT We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a. Elicited peritoneal macrophages responded to formalin-killed spherules (FKS) and alkali-treated FKS by secreting proinflam...

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Autores principales: Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2013
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Acceso en línea:https://doaj.org/article/0d26f57a83574493a5ee87b848c2e7d4
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