Theoretical model for cellular shapes driven by protrusive and adhesive forces.

The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix. We present here a theoretical model for the cellular shapes resulting from the feedback between the me...

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Autores principales:	Doron Kabaso, Roie Shlomovitz, Kathrin Schloen, Theresia Stradal, Nir S Gov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0d2a270404674e6592112b87a1286573
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spelling	oai:doaj.org-article:0d2a270404674e6592112b87a12865732021-11-18T05:50:34ZTheoretical model for cellular shapes driven by protrusive and adhesive forces.1553-734X1553-735810.1371/journal.pcbi.1001127https://doaj.org/article/0d2a270404674e6592112b87a12865732011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21573201/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix. We present here a theoretical model for the cellular shapes resulting from the feedback between the membrane shape and the forces acting on the membrane, mediated by curvature-sensitive membrane complexes of a convex shape. In previous theoretical studies we have investigated the regimes of linear instability where spontaneous formation of cellular protrusions is initiated. Here we calculate the evolution of a two dimensional cell contour beyond the linear regime and determine the final steady-state shapes arising within the model. We find that shapes driven by adhesion or by actin polymerization (lamellipodia) have very different morphologies, as observed in cells. Furthermore, we find that as the strength of the protrusive forces diminish, the system approaches a stabilization of a periodic pattern of protrusions. This result can provide an explanation for a number of puzzling experimental observations regarding cellular shape dependence on the properties of the extra-cellular matrix.Doron KabasoRoie ShlomovitzKathrin SchloenTheresia StradalNir S GovPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 5, p e1001127 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Doron Kabaso Roie Shlomovitz Kathrin Schloen Theresia Stradal Nir S Gov Theoretical model for cellular shapes driven by protrusive and adhesive forces.
description	The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix. We present here a theoretical model for the cellular shapes resulting from the feedback between the membrane shape and the forces acting on the membrane, mediated by curvature-sensitive membrane complexes of a convex shape. In previous theoretical studies we have investigated the regimes of linear instability where spontaneous formation of cellular protrusions is initiated. Here we calculate the evolution of a two dimensional cell contour beyond the linear regime and determine the final steady-state shapes arising within the model. We find that shapes driven by adhesion or by actin polymerization (lamellipodia) have very different morphologies, as observed in cells. Furthermore, we find that as the strength of the protrusive forces diminish, the system approaches a stabilization of a periodic pattern of protrusions. This result can provide an explanation for a number of puzzling experimental observations regarding cellular shape dependence on the properties of the extra-cellular matrix.
format	article
author	Doron Kabaso Roie Shlomovitz Kathrin Schloen Theresia Stradal Nir S Gov
author_facet	Doron Kabaso Roie Shlomovitz Kathrin Schloen Theresia Stradal Nir S Gov
author_sort	Doron Kabaso
title	Theoretical model for cellular shapes driven by protrusive and adhesive forces.
title_short	Theoretical model for cellular shapes driven by protrusive and adhesive forces.
title_full	Theoretical model for cellular shapes driven by protrusive and adhesive forces.
title_fullStr	Theoretical model for cellular shapes driven by protrusive and adhesive forces.
title_full_unstemmed	Theoretical model for cellular shapes driven by protrusive and adhesive forces.
title_sort	theoretical model for cellular shapes driven by protrusive and adhesive forces.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0d2a270404674e6592112b87a1286573
work_keys_str_mv	AT doronkabaso theoreticalmodelforcellularshapesdrivenbyprotrusiveandadhesiveforces AT roieshlomovitz theoreticalmodelforcellularshapesdrivenbyprotrusiveandadhesiveforces AT kathrinschloen theoreticalmodelforcellularshapesdrivenbyprotrusiveandadhesiveforces AT theresiastradal theoreticalmodelforcellularshapesdrivenbyprotrusiveandadhesiveforces AT nirsgov theoreticalmodelforcellularshapesdrivenbyprotrusiveandadhesiveforces
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Theoretical model for cellular shapes driven by protrusive and adhesive forces.

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