Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

ABSTRACT In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P. falciparum, we identified a loss-of-function mutation in HAD2 (P. falciparum 3D7_1226300...

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Autores principales: Ann M. Guggisberg, Philip M. Frasse, Andrew J. Jezewski, Natasha M. Kafai, Aakash Y. Gandhi, Samuel J. Erlinger, Audrey R. Odom John
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
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Acceso en línea:https://doaj.org/article/0d2cdb80aa98443e8071149bc2d037ca
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