Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. The authors show that depletion of macrophages in the dorsal root ganglia prevents and reverses ongoing nerve injury-induced hypersensitivity.

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Autores principales:	Xiaobing Yu, Hongju Liu, Katherine A. Hamel, Maelig G. Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M. Braz, Allan I. Basbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d2d77d7fa8e4d94b8e034d798ce04f1
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spelling	oai:doaj.org-article:0d2d77d7fa8e4d94b8e034d798ce04f12021-12-02T14:40:41ZDorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain10.1038/s41467-019-13839-22041-1723https://doaj.org/article/0d2d77d7fa8e4d94b8e034d798ce04f12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13839-2https://doaj.org/toc/2041-1723Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. The authors show that depletion of macrophages in the dorsal root ganglia prevents and reverses ongoing nerve injury-induced hypersensitivity.Xiaobing YuHongju LiuKatherine A. HamelMaelig G. MorvanStephen YuJacqueline LeffZhonghui GuanJoao M. BrazAllan I. BasbaumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaobing Yu Hongju Liu Katherine A. Hamel Maelig G. Morvan Stephen Yu Jacqueline Leff Zhonghui Guan Joao M. Braz Allan I. Basbaum Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
description	Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. The authors show that depletion of macrophages in the dorsal root ganglia prevents and reverses ongoing nerve injury-induced hypersensitivity.
format	article
author	Xiaobing Yu Hongju Liu Katherine A. Hamel Maelig G. Morvan Stephen Yu Jacqueline Leff Zhonghui Guan Joao M. Braz Allan I. Basbaum
author_facet	Xiaobing Yu Hongju Liu Katherine A. Hamel Maelig G. Morvan Stephen Yu Jacqueline Leff Zhonghui Guan Joao M. Braz Allan I. Basbaum
author_sort	Xiaobing Yu
title	Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
title_short	Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
title_full	Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
title_fullStr	Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
title_full_unstemmed	Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
title_sort	dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0d2d77d7fa8e4d94b8e034d798ce04f1
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Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

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