Armc5 deletion causes developmental defects and compromises T-cell immune responses

Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival andin vivoT-cell-mediated immune responses.

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Autores principales:	Yan Hu, Linjiang Lao, Jianning Mao, Wei Jin, Hongyu Luo, Tania Charpentier, Shijie Qi, Junzheng Peng, Bing Hu, Mieczyslaw Martin Marcinkiewicz, Alain Lamarre, Jiangping Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d311a9e7d404d268f2692096b76319b
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spelling	oai:doaj.org-article:0d311a9e7d404d268f2692096b76319b2021-12-02T14:40:26ZArmc5 deletion causes developmental defects and compromises T-cell immune responses10.1038/ncomms138342041-1723https://doaj.org/article/0d311a9e7d404d268f2692096b76319b2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms13834https://doaj.org/toc/2041-1723Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival andin vivoT-cell-mediated immune responses.Yan HuLinjiang LaoJianning MaoWei JinHongyu LuoTania CharpentierShijie QiJunzheng PengBing HuMieczyslaw Martin MarcinkiewiczAlain LamarreJiangping WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Hu Linjiang Lao Jianning Mao Wei Jin Hongyu Luo Tania Charpentier Shijie Qi Junzheng Peng Bing Hu Mieczyslaw Martin Marcinkiewicz Alain Lamarre Jiangping Wu Armc5 deletion causes developmental defects and compromises T-cell immune responses
description	Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival andin vivoT-cell-mediated immune responses.
format	article
author	Yan Hu Linjiang Lao Jianning Mao Wei Jin Hongyu Luo Tania Charpentier Shijie Qi Junzheng Peng Bing Hu Mieczyslaw Martin Marcinkiewicz Alain Lamarre Jiangping Wu
author_facet	Yan Hu Linjiang Lao Jianning Mao Wei Jin Hongyu Luo Tania Charpentier Shijie Qi Junzheng Peng Bing Hu Mieczyslaw Martin Marcinkiewicz Alain Lamarre Jiangping Wu
author_sort	Yan Hu
title	Armc5 deletion causes developmental defects and compromises T-cell immune responses
title_short	Armc5 deletion causes developmental defects and compromises T-cell immune responses
title_full	Armc5 deletion causes developmental defects and compromises T-cell immune responses
title_fullStr	Armc5 deletion causes developmental defects and compromises T-cell immune responses
title_full_unstemmed	Armc5 deletion causes developmental defects and compromises T-cell immune responses
title_sort	armc5 deletion causes developmental defects and compromises t-cell immune responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d311a9e7d404d268f2692096b76319b
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Armc5 deletion causes developmental defects and compromises T-cell immune responses

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