Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction

Zhen Yuan, Dongyan Cao, Mei Yu, Huimei Zhou, Ying Zhang, Jiaxin Yang, Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Dongyan CaoD...

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Autores principales:	Yuan Z, Cao D, Yu M, Zhou H, Zhang Y, Yang J, Shen K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cerebral infarction surgery ovarian neoplasms prognosis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0d311e8fde7f4b8396e1da823c152421
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spelling	oai:doaj.org-article:0d311e8fde7f4b8396e1da823c1524212021-12-02T12:18:46ZImportance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction1178-1998https://doaj.org/article/0d311e8fde7f4b8396e1da823c1524212020-02-01T00:00:00Zhttps://www.dovepress.com/importance-of-standard-treatment-in-prognosis-of-patients-with-ovarian-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhen Yuan, Dongyan Cao, Mei Yu, Huimei Zhou, Ying Zhang, Jiaxin Yang, Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Dongyan CaoDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Road, Dongcheng District, Beijing 100730, People’s Republic of ChinaEmail caodongyanpumch@sina.comObjective: Data on the treatment of patients with ovarian cancer (OC) and associated cerebral infarction (CI) are extremely limited. The objectives were to investigate the risk factors for prognosis in patients with OC and associated CI.Methods: We retrospectively reviewed the electronic medical records of patients with OC from January 2013 to November 2018 in Peking Union Medical Hospital.Results: In total, 2632 inpatients were diagnosed with malignant ovarian cancer in our institution, and 30 patients (1.1%) were diagnosed with OC-associated CI. The median age was 60 years (range, 37– 83). The standard treatment, according to National Comprehensive Cancer Network (NCCN) guidelines, was administered to 19 patients. The median follow-up time was 19.5 months (range, 1– 59 months). In total, 17 patients experienced tumor progression, and 16 of them died. In univariate analysis, overall survival was significantly associated with the D-dimer level (P=0.017), FIGO stage (P=0.014), complete cytoreduction (P< 0.000) and standard treatment (P< 0.000). In multivariate analysis, the standard treatment remained an independent protective factor for death (hazard ratio=0.061, 95% confidence interval=0.007– 0.537, P=0.012).Conclusion: Although the prognosis of patients with OC and associated CI was poor, those who underwent the standard treatment still benefited.Keywords: cerebral infarction, surgery, ovarian neoplasms, prognosisYuan ZCao DYu MZhou HZhang YYang JShen KDove Medical Pressarticlecerebral infarctionsurgeryovarian neoplasmsprognosisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 151-157 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral infarction surgery ovarian neoplasms prognosis Geriatrics RC952-954.6
spellingShingle	cerebral infarction surgery ovarian neoplasms prognosis Geriatrics RC952-954.6 Yuan Z Cao D Yu M Zhou H Zhang Y Yang J Shen K Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
description	Zhen Yuan, Dongyan Cao, Mei Yu, Huimei Zhou, Ying Zhang, Jiaxin Yang, Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Dongyan CaoDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Road, Dongcheng District, Beijing 100730, People’s Republic of ChinaEmail caodongyanpumch@sina.comObjective: Data on the treatment of patients with ovarian cancer (OC) and associated cerebral infarction (CI) are extremely limited. The objectives were to investigate the risk factors for prognosis in patients with OC and associated CI.Methods: We retrospectively reviewed the electronic medical records of patients with OC from January 2013 to November 2018 in Peking Union Medical Hospital.Results: In total, 2632 inpatients were diagnosed with malignant ovarian cancer in our institution, and 30 patients (1.1%) were diagnosed with OC-associated CI. The median age was 60 years (range, 37– 83). The standard treatment, according to National Comprehensive Cancer Network (NCCN) guidelines, was administered to 19 patients. The median follow-up time was 19.5 months (range, 1– 59 months). In total, 17 patients experienced tumor progression, and 16 of them died. In univariate analysis, overall survival was significantly associated with the D-dimer level (P=0.017), FIGO stage (P=0.014), complete cytoreduction (P< 0.000) and standard treatment (P< 0.000). In multivariate analysis, the standard treatment remained an independent protective factor for death (hazard ratio=0.061, 95% confidence interval=0.007– 0.537, P=0.012).Conclusion: Although the prognosis of patients with OC and associated CI was poor, those who underwent the standard treatment still benefited.Keywords: cerebral infarction, surgery, ovarian neoplasms, prognosis
format	article
author	Yuan Z Cao D Yu M Zhou H Zhang Y Yang J Shen K
author_facet	Yuan Z Cao D Yu M Zhou H Zhang Y Yang J Shen K
author_sort	Yuan Z
title	Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
title_short	Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
title_full	Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
title_fullStr	Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
title_full_unstemmed	Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction
title_sort	importance of standard treatment in prognosis of patients with ovarian cancer and associated cerebral infarction
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0d311e8fde7f4b8396e1da823c152421
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Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction

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