Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin

The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE comp...

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Autores principales:	Kirill Grushin, Jing Wang, Jeff Coleman, James E. Rothman, Charles V. Sindelar, Shyam S. Krishnakumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d3353b42fb54d0b8fe35dd6b8452acc
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spelling	oai:doaj.org-article:0d3353b42fb54d0b8fe35dd6b8452acc2021-12-02T17:01:59ZStructural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin10.1038/s41467-019-10391-x2041-1723https://doaj.org/article/0d3353b42fb54d0b8fe35dd6b8452acc2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10391-xhttps://doaj.org/toc/2041-1723The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE complex on a lipid membrane at 10 Å resolution.Kirill GrushinJing WangJeff ColemanJames E. RothmanCharles V. SindelarShyam S. KrishnakumarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kirill Grushin Jing Wang Jeff Coleman James E. Rothman Charles V. Sindelar Shyam S. Krishnakumar Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
description	The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE complex on a lipid membrane at 10 Å resolution.
format	article
author	Kirill Grushin Jing Wang Jeff Coleman James E. Rothman Charles V. Sindelar Shyam S. Krishnakumar
author_facet	Kirill Grushin Jing Wang Jeff Coleman James E. Rothman Charles V. Sindelar Shyam S. Krishnakumar
author_sort	Kirill Grushin
title	Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
title_short	Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
title_full	Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
title_fullStr	Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
title_full_unstemmed	Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
title_sort	structural basis for the clamping and ca2+ activation of snare-mediated fusion by synaptotagmin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d3353b42fb54d0b8fe35dd6b8452acc
work_keys_str_mv	AT kirillgrushin structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin AT jingwang structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin AT jeffcoleman structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin AT jameserothman structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin AT charlesvsindelar structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin AT shyamskrishnakumar structuralbasisfortheclampingandca2activationofsnaremediatedfusionbysynaptotagmin
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Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin

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