Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin

The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE comp...

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Autores principales: Kirill Grushin, Jing Wang, Jeff Coleman, James E. Rothman, Charles V. Sindelar, Shyam S. Krishnakumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0d3353b42fb54d0b8fe35dd6b8452acc
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