Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response

Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response

Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces cardiomyopathy, leading to congestive heart failure through the intramyocardial production of reactive oxygen species (ROS). Icariin (Ica) is a flavonoid isolated from Epimedii Herba (Berberidaceae). Some reports on the phar...

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Main Authors: Miriam Scicchitano, Cristina Carresi, Saverio Nucera, Stefano Ruga, Jessica Maiuolo, Roberta Macrì, Federica Scarano, Francesca Bosco, Rocco Mollace, Antonio Cardamone, Anna Rita Coppoletta, Lorenza Guarnieri, Maria Caterina Zito, Irene Bava, Luca Cariati, Marta Greco, Daniela Patrizia Foti, Ernesto Palma, Micaela Gliozzi, Vincenzo Musolino, Vincenzo Mollace
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cardiomyoblasts
Doxorubicin
Icariin
oxidative stress
autophagy
Nutrition. Foods and food supply
TX341-641
Online Access:https://doaj.org/article/0d3516619e54407092e9017002a7de8a
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