Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.

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Autores principales:	Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, Myeong Youl Lee, Chang Woo Lee, Jieun Yun, Soo Jin Oh, Jong Soon Kang, Susan A. Martinis, Kwang Yeon Hwang, Min Guo, Gyoonhee Han, Jung Min Han, Sunghoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d36499938674c89bf88e38b120784b7
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spelling	oai:doaj.org-article:0d36499938674c89bf88e38b120784b72021-12-02T14:40:56ZControl of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction10.1038/s41467-017-00785-02041-1723https://doaj.org/article/0d36499938674c89bf88e38b120784b72017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00785-0https://doaj.org/toc/2041-1723Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.Jong Hyun KimChulho LeeMinji LeeHaipeng WangKibum KimSeung Joon ParkIna YoonJayun JangHanchao ZhaoHoi Kyoung KimNam Hoon KwonSeung Jae JeongHee Chan YooJae Hyun KimJee Sun YangMyeong Youl LeeChang Woo LeeJieun YunSoo Jin OhJong Soon KangSusan A. MartinisKwang Yeon HwangMin GuoGyoonhee HanJung Min HanSunghoon KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jong Hyun Kim Chulho Lee Minji Lee Haipeng Wang Kibum Kim Seung Joon Park Ina Yoon Jayun Jang Hanchao Zhao Hoi Kyoung Kim Nam Hoon Kwon Seung Jae Jeong Hee Chan Yoo Jae Hyun Kim Jee Sun Yang Myeong Youl Lee Chang Woo Lee Jieun Yun Soo Jin Oh Jong Soon Kang Susan A. Martinis Kwang Yeon Hwang Min Guo Gyoonhee Han Jung Min Han Sunghoon Kim Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
description	Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.
format	article
author	Jong Hyun Kim Chulho Lee Minji Lee Haipeng Wang Kibum Kim Seung Joon Park Ina Yoon Jayun Jang Hanchao Zhao Hoi Kyoung Kim Nam Hoon Kwon Seung Jae Jeong Hee Chan Yoo Jae Hyun Kim Jee Sun Yang Myeong Youl Lee Chang Woo Lee Jieun Yun Soo Jin Oh Jong Soon Kang Susan A. Martinis Kwang Yeon Hwang Min Guo Gyoonhee Han Jung Min Han Sunghoon Kim
author_facet	Jong Hyun Kim Chulho Lee Minji Lee Haipeng Wang Kibum Kim Seung Joon Park Ina Yoon Jayun Jang Hanchao Zhao Hoi Kyoung Kim Nam Hoon Kwon Seung Jae Jeong Hee Chan Yoo Jae Hyun Kim Jee Sun Yang Myeong Youl Lee Chang Woo Lee Jieun Yun Soo Jin Oh Jong Soon Kang Susan A. Martinis Kwang Yeon Hwang Min Guo Gyoonhee Han Jung Min Han Sunghoon Kim
author_sort	Jong Hyun Kim
title	Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
title_short	Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
title_full	Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
title_fullStr	Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
title_full_unstemmed	Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
title_sort	control of leucine-dependent mtorc1 pathway through chemical intervention of leucyl-trna synthetase and ragd interaction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0d36499938674c89bf88e38b120784b7
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Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

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