Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its catalytic activity, and demonstrate that the leucine sensor function of LRS can be a new target for mTORC1 inhibition.
Guardado en:
Autores principales: | Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, Myeong Youl Lee, Chang Woo Lee, Jieun Yun, Soo Jin Oh, Jong Soon Kang, Susan A. Martinis, Kwang Yeon Hwang, Min Guo, Gyoonhee Han, Jung Min Han, Sunghoon Kim |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0d36499938674c89bf88e38b120784b7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Rag2 Deficiency Enhances Susceptibility to Systemic Mouse Adenovirus Type 1 Infection
por: Han-Kyul Lee, et al.
Publicado: (2021) -
Beta-blockers provide a differential survival benefit in patients with coronary artery disease undergoing contemporary post-percutaneous coronary intervention management
por: Pil Hyung Lee, et al.
Publicado: (2020) -
Experimental Investigation of the Ash Deposition Characteristics of Biomass Pretreated by Ash Removal during Co-Combustion with Sub-Bituminous Coal
por: Dae-Gyun Lee, et al.
Publicado: (2021) -
Differential expression of acetylcholinesterase 1 in response to various stress factors in honey bee workers
por: Sanghyeon Kim, et al.
Publicado: (2019) -
The reasons for ceramic-on-ceramic revisions between the third- and fourth-generation bearings in total hip arthroplasty from multicentric registry data
por: Sang-Min Kim, et al.
Publicado: (2021)