Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection

ABSTRACT Recent advances in the analysis of microbial communities colonizing the human body have identified a resident microbial community in the human urinary tract (UT). Compared to many other microbial niches, the human UT harbors a relatively low biomass. Studies have identified many genera and...

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Autores principales:	Michael L. Neugent, Neha V. Hulyalkar, Vivian H. Nguyen, Philippe E. Zimmern, Nicole J. De Nisco
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	metagenomics microbial communities microbiome probiotics urinary tract infection Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0d3702d383b04b7fb9afdd28ba07e787
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spelling	oai:doaj.org-article:0d3702d383b04b7fb9afdd28ba07e7872021-11-15T15:57:03ZAdvances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection10.1128/mBio.00218-202150-7511https://doaj.org/article/0d3702d383b04b7fb9afdd28ba07e7872020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00218-20https://doaj.org/toc/2150-7511ABSTRACT Recent advances in the analysis of microbial communities colonizing the human body have identified a resident microbial community in the human urinary tract (UT). Compared to many other microbial niches, the human UT harbors a relatively low biomass. Studies have identified many genera and species that may constitute a core urinary microbiome. However, the contribution of the UT microbiome to urinary tract infection (UTI) and recurrent UTI (rUTI) pathobiology is not yet clearly understood. Evidence suggests that commensal species within the UT and urogenital tract (UGT) microbiomes, such as Lactobacillus crispatus, may act to protect against colonization with uropathogens. However, the mechanisms and fundamental biology of the urinary microbiome-host relationship are not understood. The ability to measure and characterize the urinary microbiome has been enabled through the development of next-generation sequencing and bioinformatic platforms that allow for the unbiased detection of resident microbial DNA. Translating technological advances into clinical insight will require further study of the microbial and genomic ecology of the urinary microbiome in both health and disease. Future diagnostic, prognostic, and therapeutic options for the management of UTI may soon incorporate efforts to measure, restore, and/or preserve the native, healthy ecology of the urinary microbiomes.Michael L. NeugentNeha V. HulyalkarVivian H. NguyenPhilippe E. ZimmernNicole J. De NiscoAmerican Society for Microbiologyarticlemetagenomicsmicrobial communitiesmicrobiomeprobioticsurinary tract infectionMicrobiologyQR1-502ENmBio, Vol 11, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metagenomics microbial communities microbiome probiotics urinary tract infection Microbiology QR1-502
spellingShingle	metagenomics microbial communities microbiome probiotics urinary tract infection Microbiology QR1-502 Michael L. Neugent Neha V. Hulyalkar Vivian H. Nguyen Philippe E. Zimmern Nicole J. De Nisco Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
description	ABSTRACT Recent advances in the analysis of microbial communities colonizing the human body have identified a resident microbial community in the human urinary tract (UT). Compared to many other microbial niches, the human UT harbors a relatively low biomass. Studies have identified many genera and species that may constitute a core urinary microbiome. However, the contribution of the UT microbiome to urinary tract infection (UTI) and recurrent UTI (rUTI) pathobiology is not yet clearly understood. Evidence suggests that commensal species within the UT and urogenital tract (UGT) microbiomes, such as Lactobacillus crispatus, may act to protect against colonization with uropathogens. However, the mechanisms and fundamental biology of the urinary microbiome-host relationship are not understood. The ability to measure and characterize the urinary microbiome has been enabled through the development of next-generation sequencing and bioinformatic platforms that allow for the unbiased detection of resident microbial DNA. Translating technological advances into clinical insight will require further study of the microbial and genomic ecology of the urinary microbiome in both health and disease. Future diagnostic, prognostic, and therapeutic options for the management of UTI may soon incorporate efforts to measure, restore, and/or preserve the native, healthy ecology of the urinary microbiomes.
format	article
author	Michael L. Neugent Neha V. Hulyalkar Vivian H. Nguyen Philippe E. Zimmern Nicole J. De Nisco
author_facet	Michael L. Neugent Neha V. Hulyalkar Vivian H. Nguyen Philippe E. Zimmern Nicole J. De Nisco
author_sort	Michael L. Neugent
title	Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
title_short	Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
title_full	Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
title_fullStr	Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
title_full_unstemmed	Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection
title_sort	advances in understanding the human urinary microbiome and its potential role in urinary tract infection
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/0d3702d383b04b7fb9afdd28ba07e787
work_keys_str_mv	AT michaellneugent advancesinunderstandingthehumanurinarymicrobiomeanditspotentialroleinurinarytractinfection AT nehavhulyalkar advancesinunderstandingthehumanurinarymicrobiomeanditspotentialroleinurinarytractinfection AT vivianhnguyen advancesinunderstandingthehumanurinarymicrobiomeanditspotentialroleinurinarytractinfection AT philippeezimmern advancesinunderstandingthehumanurinarymicrobiomeanditspotentialroleinurinarytractinfection AT nicolejdenisco advancesinunderstandingthehumanurinarymicrobiomeanditspotentialroleinurinarytractinfection
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Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection

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