Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute to tumorigenesis.

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Autores principales:	James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d39746c3dc44914b53cf2c2f0ee8062
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spelling	oai:doaj.org-article:0d39746c3dc44914b53cf2c2f0ee80622021-12-02T15:35:52ZInactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions10.1038/s41467-019-10966-82041-1723https://doaj.org/article/0d39746c3dc44914b53cf2c2f0ee80622019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10966-8https://doaj.org/toc/2041-1723OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute to tumorigenesis.James R. BirtleyMohammad AlomaryElisa ZaniniJane AntonyZachary MabenGrant C. WeaverClaudia Von ArxManuela MuraAline T. MarinhoHaonan LuEloise V. N. MorecroftEvdoxia KaraliNaomi E. ChayenEdward W. TateMollie JurewiczLawrence J. SternChiara RecchiHani GabraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James R. Birtley Mohammad Alomary Elisa Zanini Jane Antony Zachary Maben Grant C. Weaver Claudia Von Arx Manuela Mura Aline T. Marinho Haonan Lu Eloise V. N. Morecroft Evdoxia Karali Naomi E. Chayen Edward W. Tate Mollie Jurewicz Lawrence J. Stern Chiara Recchi Hani Gabra Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
description	OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contribute to tumorigenesis.
format	article
author	James R. Birtley Mohammad Alomary Elisa Zanini Jane Antony Zachary Maben Grant C. Weaver Claudia Von Arx Manuela Mura Aline T. Marinho Haonan Lu Eloise V. N. Morecroft Evdoxia Karali Naomi E. Chayen Edward W. Tate Mollie Jurewicz Lawrence J. Stern Chiara Recchi Hani Gabra
author_facet	James R. Birtley Mohammad Alomary Elisa Zanini Jane Antony Zachary Maben Grant C. Weaver Claudia Von Arx Manuela Mura Aline T. Marinho Haonan Lu Eloise V. N. Morecroft Evdoxia Karali Naomi E. Chayen Edward W. Tate Mollie Jurewicz Lawrence J. Stern Chiara Recchi Hani Gabra
author_sort	James R. Birtley
title	Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
title_short	Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
title_full	Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
title_fullStr	Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
title_full_unstemmed	Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
title_sort	inactivating mutations and x-ray crystal structure of the tumor suppressor opcml reveal cancer-associated functions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d39746c3dc44914b53cf2c2f0ee8062
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Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions

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