HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.

<h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating st...

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Autores principales:	Lisie Souza Castro, Grazielli Rocha de Rezende, Fernanda Rodas Pires Fernandes, Larissa Melo Bandeira, Gabriela Alves Cesar, Barbara Vieira do Lago, Michele Soares Gomes Gouvêa, Ana R C Motta-Castro
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0d39b1f485c947ae802561939af6610d
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spelling	oai:doaj.org-article:0d39b1f485c947ae802561939af6610d2021-12-02T20:14:35ZHAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.1932-620310.1371/journal.pone.0256818https://doaj.org/article/0d39b1f485c947ae802561939af6610d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256818https://doaj.org/toc/1932-6203<h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating strains associated with HAV infection among MSM and TW in Central Brazil.<h4>Methods</h4>A cross-sectional study was conducted from November 2011 to September 2013. Serum samples were collected from 425 individuals for anti-HAV antibody testing and HAV molecular characterization. Of them, 149 (35.1%) participants were self-identified as transgender women. Statistical analysis was performed to evaluate the risk factors of HAV seropositivity.<h4>Results</h4>The seroprevalence of HAV exposure was 69.7% (95% Confidence Interval: 65.3-74.0%). Serological evidence of HAV was significantly higher in participants who self-identified as transgender women (83.2%) than MSM (62.3%). Increasing age, non-white race, and lower monthly household income were independently associated with HAV exposure among MSM. Only lower monthly household income was independently associated with HAV exposure among TW. One anti-HAV IgM positive sample, from a transgender woman (0.2%), was detected and classified as subgenotype IA.<h4>Conclusions</h4>High HAV prevalence was observed, markedly among TW. Considering the risky sexual behaviors this population is exposed to, HAV vaccination and prevention programs targeting this population should be considered to prevent outbreaks and the burden of the disease.Lisie Souza CastroGrazielli Rocha de RezendeFernanda Rodas Pires FernandesLarissa Melo BandeiraGabriela Alves CesarBarbara Vieira do LagoMichele Soares Gomes GouvêaAna R C Motta-CastroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
description	<h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating strains associated with HAV infection among MSM and TW in Central Brazil.<h4>Methods</h4>A cross-sectional study was conducted from November 2011 to September 2013. Serum samples were collected from 425 individuals for anti-HAV antibody testing and HAV molecular characterization. Of them, 149 (35.1%) participants were self-identified as transgender women. Statistical analysis was performed to evaluate the risk factors of HAV seropositivity.<h4>Results</h4>The seroprevalence of HAV exposure was 69.7% (95% Confidence Interval: 65.3-74.0%). Serological evidence of HAV was significantly higher in participants who self-identified as transgender women (83.2%) than MSM (62.3%). Increasing age, non-white race, and lower monthly household income were independently associated with HAV exposure among MSM. Only lower monthly household income was independently associated with HAV exposure among TW. One anti-HAV IgM positive sample, from a transgender woman (0.2%), was detected and classified as subgenotype IA.<h4>Conclusions</h4>High HAV prevalence was observed, markedly among TW. Considering the risky sexual behaviors this population is exposed to, HAV vaccination and prevention programs targeting this population should be considered to prevent outbreaks and the burden of the disease.
format	article
author	Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro
author_facet	Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro
author_sort	Lisie Souza Castro
title	HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
title_short	HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
title_full	HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
title_fullStr	HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
title_full_unstemmed	HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
title_sort	hav infection in brazilian men who have sex with men: the importance of surveillance to avoid outbreaks.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0d39b1f485c947ae802561939af6610d
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HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.

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