Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study

Ismail Ahmed Nagib Omar Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, Egypt Aim: To evaluate the effect of oral Difrarel on progression of high myopia in children and to study myopia course after its discontinuation.Methods: A total of 64 highly myopic children were enro...

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Autor principal:	Omar IA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	high myopia in children Difrarel bilberry extract progressive myopia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0d3eb7935c56482f82979c0280483db2
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spelling	oai:doaj.org-article:0d3eb7935c56482f82979c0280483db22021-12-02T04:21:49ZEffect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study1177-5483https://doaj.org/article/0d3eb7935c56482f82979c0280483db22018-12-01T00:00:00Zhttps://www.dovepress.com/effect-of-bilberry-extract-on-slowing-high-myopia-progression-in-child-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ismail Ahmed Nagib Omar Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, Egypt Aim: To evaluate the effect of oral Difrarel on progression of high myopia in children and to study myopia course after its discontinuation.Methods: A total of 64 highly myopic children were enrolled in this study. Patients were divided into two equal groups: group 1 was administered Difrarel for 1 year and stopped its intake for another year, and group 2 (control) did not take Difrarel. Refraction and axial length of the right eye of every subject were measured every 6 months in both groups.Results: Each group had 32 eyes of 32 patients. The mean age was 9.34±2.27 years in group 1 and 9.33±2.2 years in group 2. Mean refraction and axial length at the start of the study were -10.78±2.6 D and 23.7±1.2 mm, respectively, in group 1, and -10.5±2.55 D and 23.9±1.4 mm in group 2. Refraction and axial length measurements every 6 months revealed statistically significant lower numbers in group 1 than group 2 after 1 year. After discontinuation of the drug, the difference between both groups remained significant.Conclusion: Oral Difrarel slowed axial elongation and stopped myopia progression in children with high myopia. The drug effect was consistent after its discontinuation for 1 year. Keywords: high myopia in children, Difrarel, axial myopia, progressive myopiaOmar IADove Medical Pressarticlehigh myopia in childrenDifrarelbilberry extractprogressive myopiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2575-2579 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	high myopia in children Difrarel bilberry extract progressive myopia Ophthalmology RE1-994
spellingShingle	high myopia in children Difrarel bilberry extract progressive myopia Ophthalmology RE1-994 Omar IA Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
description	Ismail Ahmed Nagib Omar Ophthalmology Department, Faculty of Medicine, Minia University, El-Minya, Egypt Aim: To evaluate the effect of oral Difrarel on progression of high myopia in children and to study myopia course after its discontinuation.Methods: A total of 64 highly myopic children were enrolled in this study. Patients were divided into two equal groups: group 1 was administered Difrarel for 1 year and stopped its intake for another year, and group 2 (control) did not take Difrarel. Refraction and axial length of the right eye of every subject were measured every 6 months in both groups.Results: Each group had 32 eyes of 32 patients. The mean age was 9.34±2.27 years in group 1 and 9.33±2.2 years in group 2. Mean refraction and axial length at the start of the study were -10.78±2.6 D and 23.7±1.2 mm, respectively, in group 1, and -10.5±2.55 D and 23.9±1.4 mm in group 2. Refraction and axial length measurements every 6 months revealed statistically significant lower numbers in group 1 than group 2 after 1 year. After discontinuation of the drug, the difference between both groups remained significant.Conclusion: Oral Difrarel slowed axial elongation and stopped myopia progression in children with high myopia. The drug effect was consistent after its discontinuation for 1 year. Keywords: high myopia in children, Difrarel, axial myopia, progressive myopia
format	article
author	Omar IA
author_facet	Omar IA
author_sort	Omar IA
title	Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
title_short	Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
title_full	Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
title_fullStr	Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
title_full_unstemmed	Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
title_sort	effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0d3eb7935c56482f82979c0280483db2
work_keys_str_mv	AT omaria effectofbilberryextractonslowinghighmyopiaprogressioninchildren2yearfollowupstudy
_version_	1718401291995054080

Effect of bilberry extract on slowing high-myopia progression in children: 2-year follow-up study

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