Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease

Osteopontin (<i>OPN</i>) is considered a clinical predictor of cardiovascular disease. We aimed to evaluate the association of the <i>OPN</i> gene polymorphisms rs2728127 and rs11730582 with the development of premature coronary artery disease (pCAD), cardiovascular risk fact...

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Autores principales:	Nonanzit Pérez-Hernández, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Lizet Paola Hernández-Germán, Verónica Marusa Borgonio-Cuadra, José Manuel Rodríguez-Pérez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteopontin coronary artery disease polymorphic sites biomineralization metabolic abnormalities Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0d3fc223526b482388a8c8e5b6fdda97
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spelling	oai:doaj.org-article:0d3fc223526b482388a8c8e5b6fdda972021-11-25T16:49:27ZOsteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease10.3390/biomedicines91116002227-9059https://doaj.org/article/0d3fc223526b482388a8c8e5b6fdda972021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1600https://doaj.org/toc/2227-9059Osteopontin (<i>OPN</i>) is considered a clinical predictor of cardiovascular disease. We aimed to evaluate the association of the <i>OPN</i> gene polymorphisms rs2728127 and rs11730582 with the development of premature coronary artery disease (pCAD), cardiovascular risk factors, and cardiometabolic parameters. We evaluated 1142 patients with pCAD and 1073 controls. Both polymorphisms were determined by Taqman assays. Similar allele and genotype frequencies were observed in both groups; additionally, an association of these polymorphisms with CAD and cardiometabolic parameters was observed in both groups. In patients with pCAD, the rs11730582 was associated with a high risk of hypoadiponectinemia (OR = 1.300, P <sub>additive</sub> = 0.003), low risk of hypertension (OR = 0.709, P <sub>codominant 1</sub> = 0.030), and low risk of having high non-HDL cholesterol (OR = 0.637, P <sub>additive</sub> = 0.038). In the control group, the rs2728127 was associated with a low risk of fatty liver (OR = 0.766, P <sub>additive</sub> = 0.038); while the rs11730582 was associated with a low risk of hypoadiponectinemia (OR = 0.728, P <sub>dominant</sub> = 0.022), and risk of having elevated apolipoprotein B (OR = 1.400, P <sub>dominant</sub> = 0.031). Our results suggest that in Mexican individuals, the rs11730582 and rs2728127 <i>OPN</i> gene polymorphisms are associated with some abnormal metabolic variables in patients with pCAD and controls.Nonanzit Pérez-HernándezRosalinda Posadas-SánchezGilberto Vargas-AlarcónLizet Paola Hernández-GermánVerónica Marusa Borgonio-CuadraJosé Manuel Rodríguez-PérezMDPI AGarticleosteopontincoronary artery diseasepolymorphic sitesbiomineralizationmetabolic abnormalitiesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1600, p 1600 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteopontin coronary artery disease polymorphic sites biomineralization metabolic abnormalities Biology (General) QH301-705.5
spellingShingle	osteopontin coronary artery disease polymorphic sites biomineralization metabolic abnormalities Biology (General) QH301-705.5 Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Lizet Paola Hernández-Germán Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
description	Osteopontin (<i>OPN</i>) is considered a clinical predictor of cardiovascular disease. We aimed to evaluate the association of the <i>OPN</i> gene polymorphisms rs2728127 and rs11730582 with the development of premature coronary artery disease (pCAD), cardiovascular risk factors, and cardiometabolic parameters. We evaluated 1142 patients with pCAD and 1073 controls. Both polymorphisms were determined by Taqman assays. Similar allele and genotype frequencies were observed in both groups; additionally, an association of these polymorphisms with CAD and cardiometabolic parameters was observed in both groups. In patients with pCAD, the rs11730582 was associated with a high risk of hypoadiponectinemia (OR = 1.300, P <sub>additive</sub> = 0.003), low risk of hypertension (OR = 0.709, P <sub>codominant 1</sub> = 0.030), and low risk of having high non-HDL cholesterol (OR = 0.637, P <sub>additive</sub> = 0.038). In the control group, the rs2728127 was associated with a low risk of fatty liver (OR = 0.766, P <sub>additive</sub> = 0.038); while the rs11730582 was associated with a low risk of hypoadiponectinemia (OR = 0.728, P <sub>dominant</sub> = 0.022), and risk of having elevated apolipoprotein B (OR = 1.400, P <sub>dominant</sub> = 0.031). Our results suggest that in Mexican individuals, the rs11730582 and rs2728127 <i>OPN</i> gene polymorphisms are associated with some abnormal metabolic variables in patients with pCAD and controls.
format	article
author	Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Lizet Paola Hernández-Germán Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez
author_facet	Nonanzit Pérez-Hernández Rosalinda Posadas-Sánchez Gilberto Vargas-Alarcón Lizet Paola Hernández-Germán Verónica Marusa Borgonio-Cuadra José Manuel Rodríguez-Pérez
author_sort	Nonanzit Pérez-Hernández
title	Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
title_short	Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
title_full	Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
title_fullStr	Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
title_full_unstemmed	Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease
title_sort	osteopontin gene polymorphisms are associated with cardiovascular risk factors in patients with premature coronary artery disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0d3fc223526b482388a8c8e5b6fdda97
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Osteopontin Gene Polymorphisms Are Associated with Cardiovascular Risk Factors in Patients with Premature Coronary Artery Disease

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