Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis, impacting intracellular crosstalk.

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Autores principales:	Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a54
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spelling	oai:doaj.org-article:0d4577b03c594bb194303bbedd2c9a542021-12-02T15:35:26ZAcetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk10.1038/s41467-019-11945-92041-1723https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a542019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11945-9https://doaj.org/toc/2041-1723The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis, impacting intracellular crosstalk.Inca A. DieterichAlexis J. LawtonYajing PengQing YuTimothy W. RhoadsKatherine A. OvermyerYusi CuiEric A. ArmstrongPorsha R. HowellMaggie S. BurhansLingjun LiJohn M. DenuJoshua J. CoonRozalyn M. AndersonLuigi PuglielliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inca A. Dieterich Alexis J. Lawton Yajing Peng Qing Yu Timothy W. Rhoads Katherine A. Overmyer Yusi Cui Eric A. Armstrong Porsha R. Howell Maggie S. Burhans Lingjun Li John M. Denu Joshua J. Coon Rozalyn M. Anderson Luigi Puglielli Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
description	The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis, impacting intracellular crosstalk.
format	article
author	Inca A. Dieterich Alexis J. Lawton Yajing Peng Qing Yu Timothy W. Rhoads Katherine A. Overmyer Yusi Cui Eric A. Armstrong Porsha R. Howell Maggie S. Burhans Lingjun Li John M. Denu Joshua J. Coon Rozalyn M. Anderson Luigi Puglielli
author_facet	Inca A. Dieterich Alexis J. Lawton Yajing Peng Qing Yu Timothy W. Rhoads Katherine A. Overmyer Yusi Cui Eric A. Armstrong Porsha R. Howell Maggie S. Burhans Lingjun Li John M. Denu Joshua J. Coon Rozalyn M. Anderson Luigi Puglielli
author_sort	Inca A. Dieterich
title	Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
title_short	Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
title_full	Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
title_fullStr	Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
title_full_unstemmed	Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
title_sort	acetyl-coa flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a54
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Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

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