Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction

Max J Blumberg,1 Amy E Millen,2 Sangita P Patel1,3 1Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA; 2Department of Epidemiology and Environmental Sciences, School of Public Health and Healt...

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Autores principales:	Blumberg MJ, Millen AE, Patel SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	meibomian glands dry eye syndromes skin pigmentation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0d48daaf59754d8a933b5e9f2ada2174
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spelling	oai:doaj.org-article:0d48daaf59754d8a933b5e9f2ada21742021-12-02T03:07:45ZInfluence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction1177-5483https://doaj.org/article/0d48daaf59754d8a933b5e9f2ada21742019-09-01T00:00:00Zhttps://www.dovepress.com/influence-of-eyelid-pigmentation-on-the-diagnosis-of-meibomian-gland-d-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Max J Blumberg,1 Amy E Millen,2 Sangita P Patel1,3 1Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA; 2Department of Epidemiology and Environmental Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA; 3Research and Ophthalmology Services, Veterans Administration of Western New York Healthcare System, Buffalo, NY, USACorrespondence: Sangita P PatelRoss Eye Institute, 1176 Main Street, Buffalo, NY 14209, USATel +1 716 862 6577Fax +1 716 881 4349Email sppatel@buffalo.eduPurpose: To determine whether reliance on eyelid margin vascularization as a diagnostic criterion for meibomian gland dysfunction (MGD) results in underdiagnosis of MGD in individuals with dark skin pigmentation.Patients and Methods: This cross-sectional study enrolled consecutive cornea clinic patients in Buffalo, New York. Eyelid margin vascularization was graded qualitatively from slit-lamp photos. Skin pigmentation was quantified from digital photos using red/green/blue (RGB) pixel analysis and dichotomized using the RGB median. MGD was defined as abnormal quantity or quality of meibum or increased pressure required to express meibum. Additional testing included infrared meibography, Schirmer’s testing, and a dry eye questionnaire. Sensitivity of MGD diagnosis by visualization of vascularization, compared to diagnosis by expression of meibum, was estimated with and without stratification by skin pigmentation.Results: Among 47 participants, 15–79 years old, meibomian gland truncation/dropout, abnormal tear production, and dry eye symptoms affected individuals of all skin pigmentations. Eyelid margin vascularization was less common in subjects with dark (n=21%) compared to light pigmentation (65%; p=0.002), although the prevalence of MGD assessed via clinical evaluation did not vary significantly between those groups. Use of eyelid margin vascularization alone was not sensitive (33%) for MGD diagnosis. The sensitivity was 17% when limited to those with dark pigmentation.Conclusion: Our findings highlight the importance of gland expression and suggest limiting reliance on eyelid margin vascularization for MGD diagnosis, especially in those with dark eyelid skin pigmentation.Keywords: meibomian glands, dry eye syndromes, skin pigmentationBlumberg MJMillen AEPatel SPDove Medical Pressarticlemeibomian glandsdry eye syndromesskin pigmentationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1815-1821 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	meibomian glands dry eye syndromes skin pigmentation Ophthalmology RE1-994
spellingShingle	meibomian glands dry eye syndromes skin pigmentation Ophthalmology RE1-994 Blumberg MJ Millen AE Patel SP Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
description	Max J Blumberg,1 Amy E Millen,2 Sangita P Patel1,3 1Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA; 2Department of Epidemiology and Environmental Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA; 3Research and Ophthalmology Services, Veterans Administration of Western New York Healthcare System, Buffalo, NY, USACorrespondence: Sangita P PatelRoss Eye Institute, 1176 Main Street, Buffalo, NY 14209, USATel +1 716 862 6577Fax +1 716 881 4349Email sppatel@buffalo.eduPurpose: To determine whether reliance on eyelid margin vascularization as a diagnostic criterion for meibomian gland dysfunction (MGD) results in underdiagnosis of MGD in individuals with dark skin pigmentation.Patients and Methods: This cross-sectional study enrolled consecutive cornea clinic patients in Buffalo, New York. Eyelid margin vascularization was graded qualitatively from slit-lamp photos. Skin pigmentation was quantified from digital photos using red/green/blue (RGB) pixel analysis and dichotomized using the RGB median. MGD was defined as abnormal quantity or quality of meibum or increased pressure required to express meibum. Additional testing included infrared meibography, Schirmer’s testing, and a dry eye questionnaire. Sensitivity of MGD diagnosis by visualization of vascularization, compared to diagnosis by expression of meibum, was estimated with and without stratification by skin pigmentation.Results: Among 47 participants, 15–79 years old, meibomian gland truncation/dropout, abnormal tear production, and dry eye symptoms affected individuals of all skin pigmentations. Eyelid margin vascularization was less common in subjects with dark (n=21%) compared to light pigmentation (65%; p=0.002), although the prevalence of MGD assessed via clinical evaluation did not vary significantly between those groups. Use of eyelid margin vascularization alone was not sensitive (33%) for MGD diagnosis. The sensitivity was 17% when limited to those with dark pigmentation.Conclusion: Our findings highlight the importance of gland expression and suggest limiting reliance on eyelid margin vascularization for MGD diagnosis, especially in those with dark eyelid skin pigmentation.Keywords: meibomian glands, dry eye syndromes, skin pigmentation
format	article
author	Blumberg MJ Millen AE Patel SP
author_facet	Blumberg MJ Millen AE Patel SP
author_sort	Blumberg MJ
title	Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
title_short	Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
title_full	Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
title_fullStr	Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
title_full_unstemmed	Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
title_sort	influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0d48daaf59754d8a933b5e9f2ada2174
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Influence of eyelid pigmentation on the diagnosis of meibomian gland dysfunction

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