Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)

This study was designed to examine the potentials of telomere length, mitochondria, and acute phase protein genes as novel biomarkers of gastrointestinal (GI) tract pathologies and meat quality traits. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and records on body weight,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kazeem Ajasa Badmus, Zulkifli Idrus, Goh Yong Meng, Kamalludin Mamat-Hamidi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	broilers corticosterone body weight GI tract meat qualities biomarkers Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/0d4bb9c8ed4044c3b0b8aaf97451cfc9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0d4bb9c8ed4044c3b0b8aaf97451cfc9
record_format	dspace
spelling	oai:doaj.org-article:0d4bb9c8ed4044c3b0b8aaf97451cfc92021-11-25T16:20:21ZTelomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)10.3390/ani111132762076-2615https://doaj.org/article/0d4bb9c8ed4044c3b0b8aaf97451cfc92021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3276https://doaj.org/toc/2076-2615This study was designed to examine the potentials of telomere length, mitochondria, and acute phase protein genes as novel biomarkers of gastrointestinal (GI) tract pathologies and meat quality traits. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and records on body weight, telomere length, GI tract and muscle histopathological test, meat quality traits, mitochondria, and acute phase protein genes were obtained at weeks 4 and 6 of age. The body weight of CORT-fed chickens was significantly suppressed (<i>p <</i> 0.05). CORT significantly altered the GI tract and meat quality traits. The interaction effect of CORT and age on body weight, duodenum and ileum crypt depth, pH, and meat color was significant (<i>p <</i> 0.05). CORT significantly (<i>p <</i> 0.05) shortened buffy coat telomere length. <i>UCP3</i> and <i>COX6A1</i> were diversely and significantly expressed in the muscle, liver, and heart of the CORT-fed chicken. Significant expression of <i>SAAL1</i> and <i>CRP</i> in the liver and hypothalamus of the CORT-fed chickens was observed at week 4 and 6. Therefore, telomere lengths, mitochondria, and acute phase protein genes could be used as novel biomarkers for GI tract pathologies and meat quality traits.Kazeem Ajasa BadmusZulkifli IdrusGoh Yong MengKamalludin Mamat-HamidiMDPI AGarticlebroilerscorticosteronebody weightGI tractmeat qualitiesbiomarkersVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3276, p 3276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	broilers corticosterone body weight GI tract meat qualities biomarkers Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	broilers corticosterone body weight GI tract meat qualities biomarkers Veterinary medicine SF600-1100 Zoology QL1-991 Kazeem Ajasa Badmus Zulkifli Idrus Goh Yong Meng Kamalludin Mamat-Hamidi Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
description	This study was designed to examine the potentials of telomere length, mitochondria, and acute phase protein genes as novel biomarkers of gastrointestinal (GI) tract pathologies and meat quality traits. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and records on body weight, telomere length, GI tract and muscle histopathological test, meat quality traits, mitochondria, and acute phase protein genes were obtained at weeks 4 and 6 of age. The body weight of CORT-fed chickens was significantly suppressed (<i>p <</i> 0.05). CORT significantly altered the GI tract and meat quality traits. The interaction effect of CORT and age on body weight, duodenum and ileum crypt depth, pH, and meat color was significant (<i>p <</i> 0.05). CORT significantly (<i>p <</i> 0.05) shortened buffy coat telomere length. <i>UCP3</i> and <i>COX6A1</i> were diversely and significantly expressed in the muscle, liver, and heart of the CORT-fed chicken. Significant expression of <i>SAAL1</i> and <i>CRP</i> in the liver and hypothalamus of the CORT-fed chickens was observed at week 4 and 6. Therefore, telomere lengths, mitochondria, and acute phase protein genes could be used as novel biomarkers for GI tract pathologies and meat quality traits.
format	article
author	Kazeem Ajasa Badmus Zulkifli Idrus Goh Yong Meng Kamalludin Mamat-Hamidi
author_facet	Kazeem Ajasa Badmus Zulkifli Idrus Goh Yong Meng Kamalludin Mamat-Hamidi
author_sort	Kazeem Ajasa Badmus
title	Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
title_short	Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
title_full	Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
title_fullStr	Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
title_full_unstemmed	Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)
title_sort	telomere length, apoptotic, and inflammatory genes: novel biomarkers of gastrointestinal tract pathology and meat quality traits in chickens under chronic stress (<i>gallus gallus domesticus</i>)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0d4bb9c8ed4044c3b0b8aaf97451cfc9
work_keys_str_mv	AT kazeemajasabadmus telomerelengthapoptoticandinflammatorygenesnovelbiomarkersofgastrointestinaltractpathologyandmeatqualitytraitsinchickensunderchronicstressigallusgallusdomesticusi AT zulkifliidrus telomerelengthapoptoticandinflammatorygenesnovelbiomarkersofgastrointestinaltractpathologyandmeatqualitytraitsinchickensunderchronicstressigallusgallusdomesticusi AT gohyongmeng telomerelengthapoptoticandinflammatorygenesnovelbiomarkersofgastrointestinaltractpathologyandmeatqualitytraitsinchickensunderchronicstressigallusgallusdomesticusi AT kamalludinmamathamidi telomerelengthapoptoticandinflammatorygenesnovelbiomarkersofgastrointestinaltractpathologyandmeatqualitytraitsinchickensunderchronicstressigallusgallusdomesticusi
_version_	1718413180687876096

Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (<i>Gallus gallus domesticus</i>)

Ejemplares similares