Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study

Abstract Background This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were...

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Autores principales: Chuanwang Yan, Hui Yang, Lili Chen, Ran Liu, Wei Shang, Wenguang Yuan, Fei Yang, Qing Sun, Lijian Xia
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Publicado: BMC 2021
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spelling oai:doaj.org-article:0d4fa062067044b8bf655ceeb4b67c0f2021-12-05T12:19:35ZClinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study10.1186/s12885-021-09031-91471-2407https://doaj.org/article/0d4fa062067044b8bf655ceeb4b67c0f2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-09031-9https://doaj.org/toc/1471-2407Abstract Background This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. Propensity score matching (PSM) was performed according to a 1:1 ratio. Receiver-operating characteristic (ROC) curve was used to identify the optimal cut-off value of MC ratio for prognostic prediction. The clinicopathological features and 3-year overall survival (OS) of AC patients, mucinous adenocarcinoma (MAC) (MC > 50%) patients, and ACMC (1–50%) patients were compared before and after matching. Multivariable analysis was used for analyzing independent risk factors related to prognosis. Results A total of 532 patients were enrolled in this study. Patients with AC, MAC, and ACMC (1–50%) exhibited different clinicopathological features. However, their 3-year OS rates were similar (82.00% vs. 74.11% vs. 81.48%, P = 0.38). After matching, ROC curve determined 70% as the optimal cut-off value. And patients with ACMC > 70% had a much poorer 3-year OS compared with ACMC (1–70%) patients and AC patients (47.37% vs. 86.15% vs. 79.76%, P < 0.001). In addition, ACMC > 70% was revealed as a risk factor for poor survival in univariate analysis (HR = 1.643, 95%CI = 1.025–2.635, P = 0.039), though not an independent risk factor in multivariable analysis (HR = 1.550, 95%CI = 0.958–2.507, P = 0.074). Conclusions MAC is usually diagnosed at an advanced stage. MAC has a similar survival with AC and ACMC (1–50%) patients before and after matching. Patients with ACMC > 70% exhibited a much poorer OS, and should be given more clinical attention.Chuanwang YanHui YangLili ChenRan LiuWei ShangWenguang YuanFei YangQing SunLijian XiaBMCarticleColorectal cancerAdenocarcinomaMucinous componentSurvival prognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Colorectal cancer
Adenocarcinoma
Mucinous component
Survival prognosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Colorectal cancer
Adenocarcinoma
Mucinous component
Survival prognosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Chuanwang Yan
Hui Yang
Lili Chen
Ran Liu
Wei Shang
Wenguang Yuan
Fei Yang
Qing Sun
Lijian Xia
Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
description Abstract Background This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. Propensity score matching (PSM) was performed according to a 1:1 ratio. Receiver-operating characteristic (ROC) curve was used to identify the optimal cut-off value of MC ratio for prognostic prediction. The clinicopathological features and 3-year overall survival (OS) of AC patients, mucinous adenocarcinoma (MAC) (MC > 50%) patients, and ACMC (1–50%) patients were compared before and after matching. Multivariable analysis was used for analyzing independent risk factors related to prognosis. Results A total of 532 patients were enrolled in this study. Patients with AC, MAC, and ACMC (1–50%) exhibited different clinicopathological features. However, their 3-year OS rates were similar (82.00% vs. 74.11% vs. 81.48%, P = 0.38). After matching, ROC curve determined 70% as the optimal cut-off value. And patients with ACMC > 70% had a much poorer 3-year OS compared with ACMC (1–70%) patients and AC patients (47.37% vs. 86.15% vs. 79.76%, P < 0.001). In addition, ACMC > 70% was revealed as a risk factor for poor survival in univariate analysis (HR = 1.643, 95%CI = 1.025–2.635, P = 0.039), though not an independent risk factor in multivariable analysis (HR = 1.550, 95%CI = 0.958–2.507, P = 0.074). Conclusions MAC is usually diagnosed at an advanced stage. MAC has a similar survival with AC and ACMC (1–50%) patients before and after matching. Patients with ACMC > 70% exhibited a much poorer OS, and should be given more clinical attention.
format article
author Chuanwang Yan
Hui Yang
Lili Chen
Ran Liu
Wei Shang
Wenguang Yuan
Fei Yang
Qing Sun
Lijian Xia
author_facet Chuanwang Yan
Hui Yang
Lili Chen
Ran Liu
Wei Shang
Wenguang Yuan
Fei Yang
Qing Sun
Lijian Xia
author_sort Chuanwang Yan
title Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
title_short Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
title_full Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
title_fullStr Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
title_full_unstemmed Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
title_sort clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
publisher BMC
publishDate 2021
url https://doaj.org/article/0d4fa062067044b8bf655ceeb4b67c0f
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